Hee-Woong Lim

TL;DR: It is demonstrated that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl -CoA:coenzyme A within the nucleus modulates global histone acetylation levels.

TL;DR: It is shown that early B cell factor-2 (Ebf2) regulates Pparγ binding activity to determine brown versus white adipocyte identity and is identified as a key transcriptional regulator of brown fat cell fate and function.

TL;DR: Results show that Prdm16 and Prdm3 control postnatal BAT identity and function and Interestingly, the loss of brown fat identity due to ablation of PrDM16 was accelerated by concurrent deletion of the closely related PrDM3 gene.

TL;DR: It is reported that obese fat tissue of mice and humans contain multiple distinct populations of ATMs with unique tissue distributions, transcriptomes, chromatin landscapes, and functions, which provide a higher resolution of the cellular and functional heterogeneity within ATM subsets and provide a framework within which to develop new immune-directed therapies for the treatment of obesity and related sequela.

TL;DR: It is demonstrated that endocrine cells produced in vitro do not fully eliminate PcG-mediated repression on endocrine-specific genes, probably contributing to their malfunction.