Showing papers by "Risto Sankila published in 2008"
TL;DR: Given the relatively poor survival rates of oral cancer patients, cessation of tobacco and moderation of alcohol use remain the key elements in oral cancer prevention and control.
202 citations
TL;DR: Cancer incidence is increased among liver transplant patients compared to the general population, and the importance of cancer surveillance after liver transplantation is pointed out.
159 citations
TL;DR: In this article, the authors performed a retrospective survival study in 623 consecutive patients with AVM admitted to the Department of Neurosurgery in Helsinki University Hospital between 1951 and 2005, and found that AVM is associated with long-term excess mortality that may be reduced by active, even partial, treatment.
Abstract: OBJECTIVE: Long-term follow-up studies in patients with brain arteriovenous malformations (AVM) have been scarce and without proper statistical estimates of mortality. We performed a retrospective survival study in 623 consecutive patients with AVMs admitted to the Department of Neurosurgery in Helsinki University Hospital between 1951 and 2005.
METHODS: Patients were followed from admission until death or the end of 2005. Patient survival was estimated using the relative survival ratio, which provides a measure of the excess mortality experienced by the patients compared with the general Finnish population matched by age, sex, and calendar time.
RESULTS: Median follow-up was 11.9 years, and total follow-up was 10,165 person-years. Treatment was conservative in 155 patients. Total AVM occlusion was attained in 356 patients, and partial occlusion was obtained in 94 patients. Overall, 206 deaths were observed. Of these, 100 were related to AVMs. Diagnosis of AVM was associated with significant long-term excess mortality, with cumulative relative survival ratios of 0.85 (95% confidence interval, 0.81-0.88) and 0.69 (95% confidence interval, 0.62-0.75) at 10 and 30 years after admission, respectively. Men had higher excess mortality than women. The excess in mortality was highest in conservatively treated patients, intermediate in patients with partially occluded AVMs, and lowest in those with totally occluded AVMs. The subgroup with the best outcome consisted of those with totally occluded unruptured AVMs, which did not demonstrate excess mortality after the first year.
CONCLUSION: AVMs are associated with long-term excess mortality that may be reduced by active, even partial, treatment. Male patients have a higher excess mortality rate than female patients.
116 citations
TL;DR: The relative probability of parenthood following early onset cancer was overall significantly reduced by ∼50%.
Abstract: We evaluated in a population-based setting the postdiagnosis parenthood among survivors compared with the fertility patterns of siblings. Cancer patients aged 0-34 years at diagnosis were identified from the Finnish Cancer Registry (N = 25,784), and their siblings (N = 44,611) by registry linkage. Further linkage identified the offspring of the patient and sibling cohorts. The relative probabilities of parenthood for first and second births separately were estimated for male and female survivors in different diagnostic age-groups and subsites using a Cox proportional hazards model, with age as the time variable and adjusting for the birth cohort of parents. In addition, estimates were calculated for 5 diagnostic eras in all subsites combined. Compared to siblings, both female and male cancer survivors were less likely to parent at least 1 child (RR 0.46, 95% CI 0.44-0.48 and RR 0.57, 95% CI 0.54-0.60, respectively). The relative probability of parenthood was especially low in male childhood cancer survivors and female young adult cancer survivors. However, cancer patients were only slightly less likely than siblings to parent a second child, with RR 0.91, 95% CI 0.86-0.97 and RR 0.95, 95% CI 0.89-1.01 for females and males, respectively. The relative probability of parenthood increased over calendar time among young adult cancer patients. The relative probability of parenthood following early onset cancer was overall significantly reduced by approximately 50%. Parenting a second child, however, was not reduced among pediatric and adolescent survivors, and only slightly reduced among early adulthood cancer survivors compared to siblings.
110 citations
Journal Article•
TL;DR: AVMs are associated with long-term excess mortality that may be reduced by active, even partial, treatment and male patients have a higher excess mortality rate than female patients.
Abstract: OBJECTIVE: Long-term follow-up studies in patients with brain arteriovenous malformations (AVM) have been scarce and without proper statistical estimates of mortality. We performed a retrospective survival study in 623 consecutive patients with AVMs admitted to the Department of Neurosurgery in Helsinki University Hospital between 1951 and 2005. METHODS: Patients were followed from admission until death or the end of 2005. Patient survival was estimated using the relative survival ratio, which provides a measure of the excess mortality experienced by the patients compared with the general Finnish population matched by age, sex, and calendar time. RESULTS: Median follow-up was 11.9 years, and total follow-up was 10,165 person-years. Treatment was conservative in 155 patients. Total AVM occlusion was attained in 356 patients, and partial occlusion was obtained in 94 patients. Overall, 206 deaths were observed. Of these, 100 were related to AVMs. Diagnosis of AVM was associated with significant long-term excess mortality, with cumulative relative survival ratios of 0.85 (95% confidence interval, 0.81-0.88) and 0.69 (95% confidence interval, 0.62-0.75) at 10 and 30 years after admission, respectively. Men had higher excess mortality than women. The excess in mortality was highest in conservatively treated patients, intermediate in patients with partially occluded AVMs, and lowest in those with totally occluded AVMs. The subgroup with the best outcome consisted of those with totally occluded unruptured AVMs, which did not demonstrate excess mortality after the first year. CONCLUSION: AVMs are associated with long-term excess mortality that may be reduced by active, even partial, treatment. Male patients have a higher excess mortality rate than female patients.
7 citations