R
Rita Bortell
Researcher at University of Massachusetts Medical School
Publications - 61
Citations - 3533
Rita Bortell is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Insulin & Islet. The author has an hindex of 29, co-authored 61 publications receiving 3197 citations. Previous affiliations of Rita Bortell include National Institutes of Health & University of Massachusetts Amherst.
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Journal ArticleDOI
Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
Christine M. Oslowski,Takashi Hara,Takashi Hara,Takashi Hara,Bryan O'Sullivan-Murphy,Kohsuke Kanekura,Kohsuke Kanekura,Simin Lu,Simin Lu,Mariko Hara,Mariko Hara,Shinsuke Ishigaki,Lihua Julie Zhu,Emiko Hayashi,Simon T. Hui,Dale L. Greiner,Randal J. Kaufman,Rita Bortell,Fumihiko Urano,Fumihiko Urano +19 more
TL;DR: It is reported that thioredoxin-interacting protein (TXNIP) is a critical signaling node that links ER stress and inflammation and is a potential therapeutic target for diabetes and ER stress-related human diseases such as Wolfram syndrome.
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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Kathryn L. Lipson,Sonya G. Fonseca,Shinsuke Ishigaki,Linh X. Nguyen,Elizabeth Foss,Rita Bortell,Aldo A. Rossini,Fumihiko Urano +7 more
TL;DR: IRE1 signaling activated by transient exposure to high glucose uses a unique subset of downstream components and has a beneficial effect on pancreatic beta cells, and is a potential target for therapeutic regulation of insulin biosynthesis.
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Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Michael A. King,Laurence D. Covassin,Michael A. Brehm,Waldemar J. Racki,Todd Pearson,Jean Leif,J Laning,W Fodor,Oded Foreman,Lisa M. Burzenski,Thomas H. Chase,Bruce Gott,Aldo A. Rossini,Rita Bortell,Leonard D. Shultz,Dale L. Greiner +15 more
TL;DR: A robust model of xenogeneic graft‐versus‐host‐like disease (GVHD) based on intravenous injection of human PBMC into 2 Gy conditioned NOD‐scid IL2rγnull mice is reported, and interrupting the tumour necrosis factor‐α signalling cascade with etanercept delays the onset and progression of disease.
Journal ArticleDOI
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
TL;DR: Data generated in the rat have correctly predicted the outcome of several human diabetes prevention trials, notably the failure of nicotinamide and low dose parenteral and oral insulin therapies.
Journal ArticleDOI
Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription
Thomas A. Owen,Rita Bortell,S A Yocum,S L Smock,Meng Zhang,C Abate,Victoria Shalhoub,Neil Aronin,Kenneth Lynn Wright,A. J. Van Wijnen +9 more
TL;DR: Results support a model in which coordinate occupancy of the AP-1 sites in the VDRE and OC box in proliferating osteoblasts may suppress both basal level and vitamin D-enhanced osteocalcin gene transcription as well as transcription of other genes associated with osteoblast differentiation--a phenomenon the authors describe as phenotype suppression.