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Rob A. Gruters
Researcher at Erasmus University Rotterdam
Publications - 91
Citations - 5194
Rob A. Gruters is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Cytotoxic T cell & CTL*. The author has an hindex of 34, co-authored 88 publications receiving 4969 citations. Previous affiliations of Rob A. Gruters include BioMérieux & Netherlands Cancer Institute.
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Journal ArticleDOI
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
M. Tersmette,Rob A. Gruters,F. De Wolf,R. E. Y. De Goede,J. M. A. Lange,Peter Th. A. Schellekens,Jaap Goudsmit,H. G. Huisman,Frank Miedema +8 more
TL;DR: Findings indicate that variability in the biological properties of HIV isolates is one of the factors influencing the course of HIV infection.
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Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex.
M. Tersmette,R. E. Y. De Goede,B. J. M. Al,I.N. Winkel,Rob A. Gruters,H T Cuypers,H. G. Huisman,Frank Miedema +7 more
TL;DR: Evidence was obtained that the high replication rate of syncytium-inducing isolates observed during primary isolation may be due to higher infectivity of these isolates, and the finding that only syncyTium- inducing isolates could be transmitted to the H9 cell line is compatible with thisHigher infectivity.
Journal ArticleDOI
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Rob A. Gruters,Jacques Neefjes,Matthijs Tersmette,Ruud E. Y. de Goede,Abraham Tulp,H. G. Huisman,Frank Miedema,Hidde L. Ploegh +7 more
TL;DR: The glucosidase inhibitors castanospermine and dNM, but not the mannosidase inhibitor dMM, inhibited syncytium formation and interfered with infectivity, suggesting involvement of N-linked glycans in the gp120–CD4 interaction.
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Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS
C. A. van Baalen,Oscar Pontesilli,Robin C. Huisman,Anna Maria Geretti,Michèl R. Klein,F. De Wolf,Frank Miedema,Rob A. Gruters,A.D.M.E. Osterhaus +8 more
TL;DR: It is shown in twelve HIV-1-infected individuals that detection of Rev-specific CTL precursors (CTLp) early in the asymptomatic stage, as well as detection ofRev- and Tat- specific CTLp later during follow-up, inversely correlate with rapid disease progression, in agreement with the hypothesis that CTL against proteins that are important for early viral transcription and translation are of particular importance in protection from rapid Disease progression.
Journal ArticleDOI
Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.
C. J. M. Van Noesel,Rob A. Gruters,F. G. Terpstra,P. T. A. Schellekens,R. A. W. Van Lier,Frank Miedema +5 more
TL;DR: This unresponsiveness to triggering either by specific antigen in the context of autologous major histocompatibility molecules (self + X) or anti-CD3 monoclonal antibodies (MAb) in both CD4 and CD8 cells from asymptomatic HIV-infected individuals is demonstrated.