P
Peter Th. A. Schellekens
Researcher at University of Amsterdam
Publications - 39
Citations - 3834
Peter Th. A. Schellekens is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antigen & Transplantation. The author has an hindex of 18, co-authored 39 publications receiving 3786 citations. Previous affiliations of Peter Th. A. Schellekens include Slotervaartziekenhuis & VU University Amsterdam.
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Journal ArticleDOI
Prognostic Value of HIV-1 Syncytium-Inducing Phenotype for Rate of CD4+ Cell Depletion and Progression to AIDS
M. Koot,I. P. M. Keet,Aster H. V. Vos,Ruud E. Y. de Goede,Marijke T. L. Roos,Roel A. Coutinho,Frank Miedema,Peter Th. A. Schellekens,Matthijs Tersmette +8 more
TL;DR: A prospective study on the course of HIV infection among 225 HIV-1-infected homosexual men from the Amsterdam cohort was designed, finding an association between high-replicating, SI isolates with a tropism for T-cell lines and enhanced CD4+ T- cell depletion and progression to AIDS.
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Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation
Nadine Pakker,Daan W. Notermans,Rob J. de Boer,Marijke T. L. Roos,Frank de Wolf,Andrew M. Hill,John M. Leonard,Sven A. Danner,Frank Miedema,Peter Th. A. Schellekens +9 more
TL;DR: It is shown, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4-cell numbers reach a plateau.
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Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
M. Tersmette,Rob A. Gruters,F. De Wolf,R. E. Y. De Goede,J. M. A. Lange,Peter Th. A. Schellekens,Jaap Goudsmit,H. G. Huisman,Frank Miedema +8 more
TL;DR: Findings indicate that variability in the biological properties of HIV isolates is one of the factors influencing the course of HIV infection.
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Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.
M. Tersmette,J M Lange,R. E. Y. De Goede,F. De Wolf,J. K. Eeftink-Schattenkerk,Peter Th. A. Schellekens,R. A. Coutinho,J. G. Huisman,Jaap Goudsmit,Frank Miedema +9 more
TL;DR: Zidovudine treatment in the symptom-free period seemed to delay the onset of AIDS in all risk groups, although stabilisation of CD4+ cell numbers was observed only in individuals with non-syncytium-inducing HIV variants.
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Changing virus-host interactions in the course of HIV-1 infection.
Frank Miedema,L. Meyaard,M. Koot,Michèl R. Klein,Marijke T. L. Roos,Martlin Groenink,Ron A. M. Fouchier,Angélique B. van 't Wout,Matthus Tersmette,Peter Th. A. Schellekens,Hanneke Schuitemaker +10 more
TL;DR: HIV-1 isolates recovered from peripheral blood mononuclear cells of asymptomatic subjects are able to grow in phytohemagglutinin (PHA)-stimulated primary blood lymphocytes (PBL) but, in contrast to isolates