Michèl R. Klein

TL;DR: In this article, two discrete primed subpopulations are found within the circulating human CD8+ T cell subset, i.e., CD45RA−CD45R0+ cells and CD27−CD27− cells.

TL;DR: In the long-term asymptomatics, persistent HIV-1 Gag-specific CTL responses and very low numbers of HIV- 1-infectedCD4+ T cells coincided with normal and stable CD4+ counts and preserved CD3 mAb-induced T cell reactivity for more than 8 yr.

TL;DR: In this article, the authors established estimates of mass accumulation rates in 18 mostly offshore sedimentary basins in Asia since the beginning of the Cenozoic, ≈ 66.

TL;DR: Especially strong IFN-gamma responses to latency antigens were observed in latently infected individuals, suggesting that immune responses against these antIGens may contribute to controlling latent M. tuberculosis infection.

TL;DR: It is shown in twelve HIV-1-infected individuals that detection of Rev-specific CTL precursors (CTLp) early in the asymptomatic stage, as well as detection ofRev- and Tat- specific CTLp later during follow-up, inversely correlate with rapid disease progression, in agreement with the hypothesis that CTL against proteins that are important for early viral transcription and translation are of particular importance in protection from rapid Disease progression.