R
Rob W.H. Ruigrok
Researcher at Centre national de la recherche scientifique
Publications - 171
Citations - 14718
Rob W.H. Ruigrok is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Nucleoprotein & RNA. The author has an hindex of 70, co-authored 166 publications receiving 13831 citations. Previous affiliations of Rob W.H. Ruigrok include National Institute for Medical Research & European Bioinformatics Institute.
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Human herpesvirus 8 and Epstein Barr-virus in a cutaneous B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient.
Patrice Morand,Marlyse Buisson,Hélène Collandre,Bruno Chanzy,Odile Genoulaz,Marie-Joseite Bourgeat,Nicole Pinel,P Leclercq,Dominique Leroux,Vincent Maréchal,Laurent Fritsch,Rob W.H. Ruigrok,Jean-Marie Seigneurin +12 more
TL;DR: The clinical and biological features of HHV-8-and EBV-associated lymphomas could be wider than has been described to date in PEL particularly with the in vivo presence of circulating malignant dually-infected cells engaged in a spontaneous HHv-8 lytic infection.
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Structural studies on the Ebola virus matrix protein VP40 indicate that matrix proteins of enveloped RNA viruses are analogues but not homologues
TL;DR: The structural and functional aspects of the filovirus matrix protein VP40 are discussed and compared to other known matrix protein structures from vesicular stomatitis virus, influenza virus and retroviral matrix proteins.
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Enveloped particles in the serum of chronic hepatitis C patients
Marie-Anne Petit,Marjory Lièvre,Simone Peyrol,Sylvie De Sequeira,Pascale Berthillon,Rob W.H. Ruigrok,Christian Trepo +6 more
TL;DR: Immuno-gold staining gave evidence that the E1E2 complex was indeed positioned at the surface of these particles, and showed spherical particles with a rather featureless surface and with a diameter around 40 nm.
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A peptide from the adenovirus fiber shaft forms amyloid-type fibrils
Mary Luckey,Jean-François Hernandez,Gérard J. Arlaud,V. Trevor Forsyth,Rob W.H. Ruigrok,Anna Mitraki +5 more
TL;DR: Peptides corresponding to the fiber shaft could provide a model system to study mechanisms of amyloid fibril formation and failed to assemble correctly and formed amyloids‐type fibrils as assessed by electron microscopy, Congo red binding and X‐ray diffraction.
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The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a
Luiza M. Bessa,S.Yu. Guseva,Aldo R. Camacho-Zarco,Nicola Salvi,Damien Maurin,Laura Mariño Perez,Maiia Botova,Anas Malki,Max H. Nanao,Malene Ringkjøbing Jensen,Rob W.H. Ruigrok,Martin Blackledge +11 more
TL;DR: The identification of distinct linear motifs that mediate an important interaction between essential viral factors provides future targets for development of innovative strategies against COVID-19.