R
Rob W.H. Ruigrok
Researcher at Centre national de la recherche scientifique
Publications - 171
Citations - 14718
Rob W.H. Ruigrok is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Nucleoprotein & RNA. The author has an hindex of 70, co-authored 166 publications receiving 13831 citations. Previous affiliations of Rob W.H. Ruigrok include National Institute for Medical Research & European Bioinformatics Institute.
Papers
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Journal ArticleDOI
Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus
Nathalie Lejal,Bogdan Tarus,Edwige Bouguyon,Sylvie Chenavas,Nicolas Bertho,Bernard Delmas,Rob W.H. Ruigrok,Carmelo Di Primo,Anny Slama-Schwok +8 more
TL;DR: It is reported here that monomeric nucleoprotein can be inhibited by a small molecule binding in its RNA binding groove, resulting in a novel antiviral against influenza A virus.
Journal ArticleDOI
Modular organization of rabies virus phosphoprotein.
Francine C. A. Gérard,Euripedes A. Ribeiro,Cedric Leyrat,Ivan Ivanov,Danielle Blondel,Sonia Longhi,Rob W.H. Ruigrok,Marc Jamin +7 more
TL;DR: A new procedure for combining the results from multiple prediction methods and locating the boundaries between disordered regions and structured domains is devised, suggesting a conserved organization of P proteins in the Rhabdoviridae family in concatenated functional domains resembling that of the P proteinsin the Paramyxoviraceae family.
Journal ArticleDOI
Mechanisms of rabies virus neutralization.
TL;DR: The number of immunoglobulins necessary to neutralize rabies virus (CVS strain) was estimated using IgG and IgM monoclonal antibodies specific to the three antigenic sites of the glycoprotein and no correlation was found between the antigenic site recognized by the antibody and the level of inhibition.
Journal ArticleDOI
Towards an atomic resolution understanding of the influenza virus replication machinery.
TL;DR: A cryo-electron microscopy structure of the entire ribonucleoprotein complex has been determined opening the way to the construction of a quasi-atomic model of the influenza replication machinery and will have an impact on anti-influenza drug design.
Book ChapterDOI
Rabies virus transcription and replication.
TL;DR: Evidence that rabies viral transcription and replication take place in cytoplasmic inclusion bodies formed in RABV-infected cells and the role of this cellular compartmentalization is reviewed.