R
Robert B. Gibbs
Researcher at University of Pittsburgh
Publications - 104
Citations - 7008
Robert B. Gibbs is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Estrogen & Basal forebrain. The author has an hindex of 46, co-authored 103 publications receiving 6720 citations. Previous affiliations of Robert B. Gibbs include Salk Institute for Biological Studies & Rockefeller University.
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Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats.
TL;DR: It is suggested that repeated treatment with estrogen and progesterone initiated within a specific period of time after the loss of ovarian function may be effective at preventing specific negative effects of hormone deprivation on brain aging and cognitive decline.
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Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy.
TL;DR: Findings indicate that nonsynaptic pathways of communication in the median eminence should be considered as a possible mechanism of kisspeptin regulation of GnRH release, and provide an anatomical basis for reciprocal control ofkisspeptin neuronal activity by GnRH.
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Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement
TL;DR: Quantitative in situ hybridization techniques demonstrate that levels of trkA mRNA in the medial septum, and BDNF RNA in the hippocampus, are affected by physiological changes in the levels of circulating gonadal steroids and are elevated in response to acute hormone replacement.
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Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats
TL;DR: The data indicate that estrogen replacement can have significant effects on basal forebrain cholinergic function, and that some of these effects may be mediated by effects of estrogen replacement on the expression of NGF and NGF receptors.
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Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain.
TL;DR: It is demonstrated that afferent sensory stimulation, but not estrogen or progesterone, regulates c-fos gene expression within different estrogen- Concentrating and non-concentrating regions of the female rat forebrain.