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Robert B. Innis
Researcher at National Institutes of Health
Publications - 468
Citations - 34412
Robert B. Innis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Radioligand & Dopamine. The author has an hindex of 90, co-authored 455 publications receiving 32492 citations. Previous affiliations of Robert B. Innis include Yale University & Veterans Health Administration.
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Journal ArticleDOI
Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain
Paolo Zanotti-Fregonara,Vanessa N. Barth,Jeih San Liow,Sami S. Zoghbi,David T. Clark,Emily Rhoads,Edward R. Siuda,Beverly A. Heinz,Eric S. Nisenbaum,Bruce A. Dressman,Elizabeth M. Joshi,Debra Luffer-Atlas,Matthew J. Fisher,John Joseph Masters,Nancy Goebl,Kuklish Steven Lee,Cheryl L. Morse,Johannes Tauscher,Victor W. Pike,Robert B. Innis +19 more
TL;DR: 11C-LY2428703, a new PET radioligand for mGluR1 quantification, displayed promising characteristics both in vitro and in vivo in rats, as shown by PET studies conducted in wild-type and knockout mice.
Journal ArticleDOI
In vivo single-shot, proton-localized 13C MRS of rhesus monkey brain.
TL;DR: A single‐shot, proton‐localized, polarization transfer 13C spectroscopic method was proposed and implemented on a 4.7 T scanner for studying rhesus monkey brains, demonstrating excellent spectral resolution and signal‐to‐noise ratio.
Journal ArticleDOI
PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain.
Shuiyu Lu,Mohammad B. Haskali,Kevin Michael Ruley,Nicolas Dreyfus,Susan DuBois,Soumen Paul,Jeih-San Liow,Cheryl L. Morse,Aneta Kowalski,Robert L. Gladding,Jeremy Gilmore,Adrian J. Mogg,S Michelle Morin,Peter J. Lindsay-Scott,J. Craig Ruble,Nancy Kant,Sergey Shcherbinin,Vanessa N. Barth,Michael P. Johnson,Maria Cuadrado,Enrique Jambrina,Andrew J. Mannes,Hugh Nuthall,Sami S. Zoghbi,Cynthia Darshini Jesudason,Robert B. Innis,Victor W. Pike +26 more
TL;DR: The aim was to develop effective radioligands for quantifying brain O-linked-β-N-acetyl-glucosamine (O-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement.
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Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo.
Sjoerd J. Finnema,Sean R. Donohue,Sean R. Donohue,Sami S. Zoghbi,Amira K. Brown,Balázs Gulyás,Robert B. Innis,Christer Halldin,Victor W. Pike +8 more
TL;DR: Brain radioactivity uptake was highest in striatum and cerebellum, and it reached 170–270% standardized uptake value (SUV) at 120 min after injection of [11C]3 and 180% SUV at 240 min after injections of [18F]3.
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An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
Pavitra Kannan,Pavitra Kannan,Pavitra Kannan,Martin Schain,Warren W. Kretzschmar,Lora D. Weidner,Lora D. Weidner,Nicholas Mitsios,Balázs Gulyás,Hans Blom,Michael M. Gottesman,Robert B. Innis,Matthew Hall,Jan Mulder +13 more
TL;DR: It is indicated that region-specific changes in transporter densities can occur globally and locally near amyloid-beta deposits in Alzheimer’s disease, providing an explanation for conflicting results in the literature.