R
Robert C. Janzer
Researcher at University Hospital of Lausanne
Publications - 46
Citations - 31546
Robert C. Janzer is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Glioma & Myopathy. The author has an hindex of 24, co-authored 46 publications receiving 27530 citations. Previous affiliations of Robert C. Janzer include University of Lausanne.
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Journal ArticleDOI
Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay.
Nobuaki Ishii,Yutaka Sawamura,Mitsuhiro Tada,Douglas M. Daub,Robert C. Janzer,Kathleen Meagher-Villemure,Nicolas de Tribolet,Erwin G. Van Meir,Erwin G. Van Meir +8 more
TL;DR: It is concluded that p53‐gene mutations are extremely rare findings in pilocytic astrocytomas, and are absent even in those exceptional cases in which malignant progression of such tumors has occurred.
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Functionalized pyrrolidine inhibitors of human type II α-mannosidases as anti-cancer agents: Optimizing the fit to the active site
Hélène Fiaux,Douglas A. Kuntz,Daniela Hoffman,Robert C. Janzer,Sandrine Gerber-Lemaire,David R. Rose,Lucienne Juillerat-Jeanneret +6 more
TL;DR: Lead molecule demonstrated nanomolar competitive inhibition of alpha-mannosidases II and an optimal fit in the active site of Drosophila GMII by X-ray crystallography, suggesting their potential for anti-cancer therapy.
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Induction of the blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick chorioallantoic vessels by a soluble factor derived from astrocytes.
Johannes Alexander Lobrinus,L. Juillerat-Jeanneret,P. Darekar,Burkhard Schlosshauer,Robert C. Janzer +4 more
TL;DR: Results indicate that a soluble factor(s) secreted by astrocytes is capable to induce specific blood-brain barrier properties in endothelial cells of non-neural origin.
Journal ArticleDOI
Tumor cells suppress cytokine-induced nitric-oxide (NO) production in cerebral endothelial cells.
TL;DR: Results suggest that rat colon‐carcinoma cells may have developed a protective mechanism involving the release of a soluble factor which inhibit the production of nitric oxide by cerebral EC.
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Reversible emetine-induced myopathy with ECG abnormalities: a toxic myopathy.
TL;DR: A young anorexic woman is described with a history of progressive muscle weakness following chronic ingestion of syrup of ipecac that was used in an attempt at weight control, which led to gradual improvement in her condition.