N
Nicolas de Tribolet
Researcher at University of Geneva
Publications - 117
Citations - 14065
Nicolas de Tribolet is an academic researcher from University of Geneva. The author has contributed to research in topics: Glioma & Antigen. The author has an hindex of 41, co-authored 117 publications receiving 13017 citations. Previous affiliations of Nicolas de Tribolet include Discovery Institute & Geneva College.
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Journal ArticleDOI
MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
Monika E. Hegi,Annie-Claire Diserens,Thierry Gorlia,Marie-France Hamou,Nicolas de Tribolet,Nicolas de Tribolet,Michael Weller,Johan M. Kros,Johannes A. Hainfellner,Warren P. Mason,Luigi Mariani,Jacoline E C Bromberg,Peter Hau,René O. Mirimanoff,J. Gregory Cairncross,Robert C. Janzer,Roger Stupp +16 more
TL;DR: Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylation of theMGMT promoter did notHave such a benefit and were assigned to only radiotherapy.
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HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity
TL;DR: The results reveal the essential role of HH-GLI signaling in controlling the behavior of human glioma cancer stem cells and offer new therapeutic possibilities.
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Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
TL;DR: This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.
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Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide
Monika E. Hegi,Annie Claire Diserens,Sophie Godard,Pierre-Yves Dietrich,Luca Regli,Sandrine Ostermann,Philippe Otten,Guy van Melle,Nicolas de Tribolet,Nicolas de Tribolet,Roger Stupp +10 more
TL;DR: The association of the epigenetic inactivation of the DNA repair gene MGMT with better outcome in this homogenous cohort may have important implications for the design of future trials and supports efforts to deplete MGMT by O-6-benzylguanine, a noncytotoxic substrate of this enzyme.
Journal ArticleDOI
Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma
Anastasia Murat,Eugenia Migliavacca,Thierry Gorlia,Wanyu L. Lambiv,Tal Shay,Marie-France Hamou,Nicolas de Tribolet,Luca Regli,Wolfgang Wick,Mathilde C.M. Kouwenhoven,Johannes A. Hainfellner,Frank L. Heppner,Pierre-Yves Dietrich,Yitzhak Zimmer,J. Gregory Cairncross,Robert-Charles Janzer,Eytan Domany,Mauro Delorenzi,Roger Stupp,Monika E. Hegi +19 more
TL;DR: This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.