抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

The Design and Analysis of Experiments

Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

Brains, it has recently been argued, are essentially prediction machines. They are bundles of cells that support perception and action by constantly attempting to match incoming sensory inputs with top-down expectations or predictions. This is achieved using a hierarchical generative model that aims to minimize prediction error within a bidirectional cascade of cortical processing. Such accounts offer a unifying model of perception and action, illuminate the functional role of attention, and may neatly capture the special contribution of cortical processing to adaptive success. This target article critically examines this "hierarchical prediction machine" approach, concluding that it offers the best clue yet to the shape of a unified science of mind and action. Sections 1 and 2 lay out the key elements and implications of the approach. Section 3 explores a variety of pitfalls and challenges, spanning the evidential, the methodological, and the more properly conceptual. The paper ends (sections 4 and 5) by asking how such approaches might impact our more general vision of mind, experience, and agency.

/pdf/whatever-next-predictive-brains-situated-agents-and-the-epj56cs868.pdf

Whatever next? Predictive brains, situated agents, and the future of cognitive science

http://mvr.mcgill.ca/Robert/PDF-04/Ellemberg-Allen-et-al-2004.pdf

Investigating local network interactions underlying first- and second-order processing.

The information used in the output of the visual filters was examined for a blur discrimination task for which it had previously been claimed that the best human performance was with pedestal blurs of intermediate magnitude. This conclusion was verified for parameters leading to asymptotic performance for foveal and parafoveal locations. The nature of the computations underlying these visual discriminations was then assessed experimentally and by simulations. The results suggest that a frequency-based model in its simplest form cannot explain these findings. A model based on the spatial properties of filter outputs is discussed.

How are spatial filters used in fovea and parafovea

Scale selection for second-order (non-linear) stereopsis

Deprivation of visual information from one eye for a 120-minute period in normal adults results in a temporary strengthening of the patched eye’s contribution to binocular vision. This plasticity for ocular dominance in adults has been demonstrated by binocular rivalry as well as binocular fusion tasks. Here, we investigate how its dynamics depend on the duration of the monocular deprivation. Using a binocular combination task, we measure the magnitude and recovery of ocular dominance change after durations of monocular deprivation ranging from 15 to 300 minutes. Surprisingly, our results show that the dynamics are of an all-or-none form. There was virtually no significant dependence on the duration of the initial deprivation.

Robert F. Hess

Papers

Investigating local network interactions underlying first- and second-order processing.

How are spatial filters used in fovea and parafovea

Scale selection for second-order (non-linear) stereopsis

The shift in ocular dominance from short-term monocular deprivation exhibits no dependence on duration of deprivation.

The luminance-dependent nature of the visual abnormality in strabismic amblyopia.