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Robert Gryfe
Researcher at University of Toronto
Publications - 43
Citations - 6267
Robert Gryfe is an academic researcher from University of Toronto. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 22, co-authored 41 publications receiving 5854 citations. Previous affiliations of Robert Gryfe include Mount Sinai Hospital, Toronto & Cancer Care Ontario.
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Journal ArticleDOI
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
Christine Ribic,Daniel J. Sargent,Malcolm J. Moore,Malcolm J. Moore,Stephen N. Thibodeau,Amy J. French,Richard M. Goldberg,Stanley R. Hamilton,Stanley R. Hamilton,Pierre Laurent-Puig,Robert Gryfe,Lois E. Shepherd,Dongsheng Tu,Mark Redston,Steven Gallinger,Steven Gallinger +15 more
TL;DR: F fluorouracil-based adjuvant chemotherapy benefited patients with stage II or stage III colon cancer with microsatellite-stable tumors or tumors exhibiting low-frequency micros satellite instability but not those with tumors exhibiting high-frequencymicrosatellite instability.
Journal ArticleDOI
Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer.
Robert Gryfe,Hyeja Kim,Eugene T.K. Hsieh,Melyssa Aronson,Eric J. Holowaty,Shelley B. Bull,Mark Redston,Steven Gallinger +7 more
TL;DR: High-frequency microsatellite instability in colorectal cancer is independently predictive of a relatively favorable outcome and, in addition, reduces the likelihood of metastases.
Journal ArticleDOI
Prevalence of Male and Female Sexual Dysfunction Is High Following Surgery for Rectal Cancer
Samantha Hendren,Brenda I. O'Connor,Maria Liu,Tracey K. Asano,Zane Cohen,Carol J. Swallow,Helen MacRae,Robert Gryfe,Robin S. McLeod +8 more
TL;DR: Sexual problems after surgery for rectal cancer are common, multifactorial, inadequately discussed, and untreated, and efforts to prevent and treat it should be increased.
Journal ArticleDOI
Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors.
Sean P. Cleary,Robert Gryfe,Maha Guindi,Paul D. Greig,Lloyd Smith,Robert Mackenzie,Robert Mackenzie,Steven M. Strasberg,Sherif S. Hanna,Bryce R. Taylor,Bernard Langer,Steven Gallinger,Steven Gallinger +12 more
TL;DR: It is concluded that longterm survival from pancreatic adenocarcinoma is possible if the disease is identified in its early stages as well as the development and evaluation of novel screening strategies to improve early detection of this disease.
Journal Article
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Laura Mirabelli-Primdahl,Robert Gryfe,Hyeja Kim,Anna Millar,Cristina Luceri,Darlene Dale,Eric J. Holowaty,Bharati Bapat,Steven Gallinger,Mark Redston +9 more
TL;DR: Differences in the mutation profiles suggest that there may be molecular fingerprints of CTNNB1 mutations, determined by biological factors related to both tumor type and underlying pathways of genomic instability.