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Amy J. French
Researcher at Mayo Clinic
Publications - 78
Citations - 11821
Amy J. French is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Microsatellite instability & Colorectal cancer. The author has an hindex of 37, co-authored 70 publications receiving 11012 citations. Previous affiliations of Amy J. French include University of Rochester.
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Journal ArticleDOI
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
Christine Ribic,Daniel J. Sargent,Malcolm J. Moore,Malcolm J. Moore,Stephen N. Thibodeau,Amy J. French,Richard M. Goldberg,Stanley R. Hamilton,Stanley R. Hamilton,Pierre Laurent-Puig,Robert Gryfe,Lois E. Shepherd,Dongsheng Tu,Mark Redston,Steven Gallinger,Steven Gallinger +15 more
TL;DR: F fluorouracil-based adjuvant chemotherapy benefited patients with stage II or stage III colon cancer with microsatellite-stable tumors or tumors exhibiting low-frequency micros satellite instability but not those with tumors exhibiting high-frequencymicrosatellite instability.
Journal ArticleDOI
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Daniel J. Weisenberger,Kimberly D. Siegmund,Mihaela Campan,Joanne P. Young,Tiffany I. Long,Mark A Faasse,Gyeong Hoon Kang,Martin Widschwendter,Deborah Weener,Daniel D. Buchanan,Hoey Koh,Lisa A. Simms,Melissa A. Barker,Barbara A. Leggett,Joan Levine,Myungjin Kim,Amy J. French,Stephen N. Thibodeau,Jeremy R. Jass,Robert W. Haile,Peter W. Laird +20 more
TL;DR: A systematic, stepwise screen of 195 CpG island methylation markers using MethyLight technology found that CIMP-positive (CIMP+) tumors convincingly represent a distinct subset, encompassing almost all cases of tumors with BRAFmutation (odds ratio = 203).
Journal ArticleDOI
Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer
Daniel J. Sargent,Silvia Marsoni,Geneviève Monges,Stephen N. Thibodeau,Roberto Labianca,Stanley R. Hamilton,Amy J. French,Brian Kabat,Nathan R. Foster,Valter Torri,Christine Ribic,Axel Grothey,Malcolm J. Moore,Alberto Zaniboni,Jean Francois Seitz,Frank A. Sinicrope,Steven Gallinger +16 more
TL;DR: Data support MMR status assessment for patients being considered for FU therapy alone and consideration of MMR status in treatment decision making and patient stratification by MMR status may provide a more tailored approach to colon cancer adjuvant therapy.
Journal ArticleDOI
Evidence for a prostate cancer susceptibility locus on the X chromosome.
Jianfeng Xu,Deborah A. Meyers,Diha Freije,Sarah D. Isaacs,Kathy E. Wiley,Deborah Nusskern,Charles M. Ewing,Eric P. Wilkens,Piroska Bujnovszky,G. Steven Bova,Patrick C. Walsh,William B. Isaacs,Johanna Schleutker,Mika P. Matikainen,Teuvo L.J. Tammela,Tapio Visakorpi,Olli Kallioniemi,Rebecca Berry,Daniel J. Schaid,Amy J. French,Shannon K. McDonnell,Jennifer J. Schroeder,Michael L. Blute,Stephen N. Thibodeau,Henrik Grönberg,Monika Emanuelsson,Jan-Erik Damber,Anders Bergh,Björn Anders Jonsson,Jeffrey R. Smith,Joan E. Bailey-Wilson,John D. Carpten,Dietrich A. Stephan,Elizabeth M. Gillanders,Isaac Amundson,Tommi Kainu,Diana Freas-Lutz,Agnes Baffoe-Bonnie,Anne Van Aucken,Raman Sood,Francis S. Collins,Michael J. Brownstein,Jeffrey M. Trent +42 more
TL;DR: Evidence for genetic locus heterogeneity was observed and genetic mapping of the locus represents an important initial step in the identification of an X-linked gene implicated in the aetiology of HPC.
Journal Article
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.
Stephen N. Thibodeau,Amy J. French,Julie M. Cunningham,David J. Tester,Lawrence J. Burgart,Patrick C. Roche,Shannon K. McDonnell,Daniel J. Schaid,Catherine Walsh Vockley,Virginia V. Michels,Gist H. Farr,Michael J. O'Connell +11 more
TL;DR: In this paper, DNA extracted from paraffin-embedded tissue from 508 patients using 11 microsatellites localized to chromosomes 5, 8, 15, 17, and 18 was used to characterize the type of alterations at these loci and their frequency of involvement in colon cancer.