Robert H. Abeles

TL;DR: The results of the investigation of an infant with abnormalities of both the sulfur amino acids and methylmalonic acid indicate the occurrence of a hitherto unrecognized metabolic abnormality, a defective ability to accumulate the coenzymatically active derivatives of B 12 .

TL;DR: According to autopsy, this infant could not adequately metabolize B, and as a result failed to accumulate coenzymatically-active derivatives of vitamin B, in normal amounts, and it is suggested that therapeutic benefit may derive from the administration of forms of 6, that could circumvent the metabolic block, by giving substances that could stimulate the non-B, -dependent methionine-synthesizing system or by the Administration of methamphetamineionine in large doses.

TL;DR: The results indicate that cobamide coenzyme functions as an essential hydrogen-transferring agent in the cobamide-dependent ribonucleotide reductase reaction, and that transferred hydrogen attaches to carbon atom 5' of the coen enzyme deoxyadenosyl moiety.

TL;DR: It is demonstrated that human PSA (rh-PSA) has properties similar to those of native PSA isolated from human seminal fluid and Analytical ultracentifugation and dynamic light scattering indicate that PSA remains monomeric under high-salt conditions.

TL;DR: It was concluded that 1-aminoethanol is an intermediate in the reaction, and when NH4+ is omitted, no tritium transfer to acetaldehyde occurs, but the dissociation of the carbon-cobalt bond is accelerated.