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Robert Thimme
Researcher at University Medical Center Freiburg
Publications - 412
Citations - 19853
Robert Thimme is an academic researcher from University Medical Center Freiburg. The author has contributed to research in topics: Cytotoxic T cell & Medicine. The author has an hindex of 62, co-authored 327 publications receiving 16934 citations. Previous affiliations of Robert Thimme include Scripps Research Institute & University of Freiburg.
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Journal ArticleDOI
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
Robert Thimme,David W. Oldach,Kyong-Mi Chang,Kyong-Mi Chang,Carola Steiger,Stuart C. Ray,Francis V. Chisari +6 more
TL;DR: The virological and immunological features of hepatitis C virus (HCV) infection were studied weekly for 6 months after accidental needlestick exposure in five health care workers, four of whom developed acute hepatitis that progressed to chronicity while one subject cleared the virus.
Journal ArticleDOI
Genomic analysis of the host response to hepatitis C virus infection.
Andrew I. Su,John Paul Pezacki,Lisa Wodicka,Amy D. Brideau,Lubica Supekova,Robert Thimme,Stefan Wieland,Jens Bukh,Robert H. Purcell,Peter G. Schultz,Francis V. Chisari +10 more
TL;DR: Gene expression analysis of liver biopsies in acutely infected chimpanzees reveals genome-wide transcriptional changes that reflect the establishment, spread, and control of infection, and they reveal potentially unique antiviral programs associated with clearance of HCV infection.
Journal ArticleDOI
CD8+ T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection
Robert Thimme,Stefan Wieland,Carola Steiger,John Ghrayeb,Keith A. Reimann,Robert H. Purcell,Francis V. Chisari +6 more
TL;DR: It is demonstrated that CD8+ cells are the main effector cells responsible for viral clearance and disease pathogenesis during acute HBV infection, and it is suggested that viral clearance is mediated by both noncytolytic and cy tolytic effector functions of the CD8-T-cell response.
Journal ArticleDOI
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert,Desirée Schubert,Claudia Bode,Rupert Kenefeck,Tie Zheng Hou,James B. Wing,Alan Kennedy,Alla Bulashevska,Britt-Sabina Petersen,Alejandro A. Schäffer,Björn Grüning,Susanne Unger,Natalie Frede,Ulrich Baumann,Torsten Witte,Reinhold E. Schmidt,G Dueckers,Tim Niehues,Suranjith L. Seneviratne,Maria Kanariou,Carsten Speckmann,Stephan Ehl,Anne Rensing-Ehl,Klaus Warnatz,Mirzokhid Rakhmanov,Robert Thimme,Peter Hasselblatt,Florian Emmerich,Toni Cathomen,Rolf Backofen,Paul Fisch,Maximilian Seidl,Annette M. May,Annette Schmitt-Graeff,Shinji Ikemizu,Ulrich Salzer,Andre Franke,Shimon Sakaguchi,Lucy S. K. Walker,David M. Sansom,Bodo Grimbacher +40 more
TL;DR: Taking together, mutations in CTLA4 resulting inCTLA-4 haploinsufficiency or impaired ligand binding result in disrupted T and B cell homeostasis and a complex immune dysregulation syndrome.
Journal ArticleDOI
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Robert Thimme,Jens Bukh,Hans Christian Spangenberg,Stefan Wieland,Janell Pemberton,Carola Steiger,Sugantha Govindarajan,Robert H. Purcell,Francis V. Chisari +8 more
TL;DR: The results indicate that HCV spread outpaces the T cell response and thatHCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN -γ-producing T cells in the liver; and that it may not require the destruction of infected cells.