R
Robert I. Scheinman
Researcher at Anschutz Medical Campus
Publications - 58
Citations - 6050
Robert I. Scheinman is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Complement system & Arthritis. The author has an hindex of 26, co-authored 56 publications receiving 5784 citations. Previous affiliations of Robert I. Scheinman include University of Washington & University of Montana.
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Journal ArticleDOI
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
TL;DR: It is shown that the synthetic glucocorticoid dexamethasone induces the transcription of the IκBα gene, which results in an increased rate of Iκbα protein synthesis, which is predicted to markedly decrease cytokine secretion and thus effectively block the activation of the immune system.
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Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.
TL;DR: The data suggest that NF-kappa B, AP-1, and GR interact in a complex regulatory network to modulate gene expression and that cross-coupling of NF- kappa B and GR plays an important role in glucocorticoid-mediated repression of cytokine transcription.
Journal Article
Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors
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I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.
TL;DR: It is proposed that I kappa B/MAD-3 masks the NLSs of NF-kappa B and c-Rel and that this constitutes the mechanism for cytoplasmic retention of these proteins.
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Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.
Vivian P. Vu,Geoffrey Gifford,Fangfang Chen,Halli Benasutti,Guankui Wang,Guankui Wang,Ernest Groman,Ernest Groman,Robert I. Scheinman,Laura Saba,Laura Saba,Seyed Moein Moghimi,Seyed Moein Moghimi,Dmitri Simberg,Dmitri Simberg +14 more
TL;DR: It is shown that natural antibodies play a critical role in C3 opsonization of SPIO nanoworms and a range of clinically approved nanopharmaceuticals, and may determine individual complement responses to nanomedicines.