S
Seyed Moein Moghimi
Researcher at Newcastle University
Publications - 103
Citations - 9502
Seyed Moein Moghimi is an academic researcher from Newcastle University. The author has contributed to research in topics: Complement system & Classical complement pathway. The author has an hindex of 35, co-authored 95 publications receiving 8470 citations. Previous affiliations of Seyed Moein Moghimi include Durham University & University of Montana.
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Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties.
TL;DR: This article critically examines and evaluates the likely mechanisms that contribute to prolonged circulation times of sterically protected nanoparticles and liposomes and discussed theories that reconcile complement activation and opsonization with prolonged circulation time.
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Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective
TL;DR: An integrated perspective is provided on the basis of the recent application of nanoscience approaches to nanocarrier design and engineering to establish the interdependency of nanoparticle size, shape, and surface characteristics in relation to interfacial forces.
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Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Fangfang Chen,Fangfang Chen,Guankui Wang,James I. Griffin,Barbara Brenneman,Nirmal K. Banda,V. Michael Holers,Donald S. Backos,Lin-Ping Wu,Seyed Moein Moghimi,Seyed Moein Moghimi,Dmitri Simberg +11 more
TL;DR: It is shown that dextran-coated superparamagnetic iron oxide core-shell nanoworms incubated in human serum and plasma are rapidly opsonized with the third complement component (C3) via the alternative pathway, showing important insight into dynamics of protein adsorption and complement opsonization of nanomedicines.
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Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
TL;DR: PEG-mediated generation of complement activation products further provides a plausible explanation to the previously reported unexplained anaphylaxis or the referred cardiovascular collapse in sensitive animals that have received medicines containing high levels of PEG as solubilizer/carrier.