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Robert J. Swingler
Researcher at Ninewells Hospital
Publications - 46
Citations - 4678
Robert J. Swingler is an academic researcher from Ninewells Hospital. The author has contributed to research in topics: Population & Amyotrophic lateral sclerosis. The author has an hindex of 24, co-authored 40 publications receiving 4300 citations. Previous affiliations of Robert J. Swingler include University of Dundee.
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Journal ArticleDOI
Prognostic factors in ALS: A critical review
Adriano Chiò,Giancarlo Logroscino,Orla Hardiman,Robert J. Swingler,Douglas Mitchell,Ettore Beghi,Bryan G. Traynor +6 more
TL;DR: A systematic review of factors related to survival in ALS revealed the rate of symptom progression was revealed to be an independent prognostic factor, and these findings have relevant implications for the design of future trials.
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Incidence of amyotrophic lateral sclerosis in Europe
Giancarlo Logroscino,Bryan J. Traynor,Orla Hardiman,Adriano Chiò,Douglas Mitchell,Robert J. Swingler,Andrea Millul,Emma K. T. Benn,Ettore Beghi +8 more
TL;DR: Sex differences in incidence may be explained by the higher incidence of spinal onset ALS among men, and the age related disease pattern suggests that ALS occurs within a susceptible group within the population rather than being a disease of ageing.
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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
Matthew Greenway,Peter M Andersen,Carsten Russ,Sean Ennis,Susan Cashman,Colette Donaghy,Victor Patterson,Robert J. Swingler,Dairin Kieran,Jochen H. M. Prehn,Karen E. Morrison,Andrew Green,K. Ravi Acharya,Robert H. Brown,Orla Hardiman,Orla Hardiman +15 more
TL;DR: The finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS, provides further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.
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Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
Giancarlo Logroscino,Bryan J. Traynor,Orla Hardiman,Adriano Chiò,Philippe Couratier,J. D. Mitchell,Robert J. Swingler,Ettore Beghi +7 more
TL;DR: The contribution of the various population based registers is outlined, the limitations of the existing datasets are identified and a mechanism to improve the future design and output of descriptive epidemiological studies is proposed.
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The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group.
Niall Tubridy,P. O. Behan,R. Capildeo,A. Chaudhuri,Raeburn B Forbes,Clive Hawkins,Richard A. C. Hughes,Jacqueline Palace,Basil Sharrack,Robert J. Swingler,Carolyn A Young,I. F. Moseley,D. G. MacManus,S. Donoghue,DH Miller +14 more
TL;DR: Short-term treatment with monoclonal antibody against alpha4 integrin results in a significant reduction in the number of new active lesions on MRI, and further studies are required to determine the longer term effect of this treatment on MRI and clinical outcomes.