R
Robert M. Sears
Researcher at New York University
Publications - 30
Citations - 2903
Robert M. Sears is an academic researcher from New York University. The author has contributed to research in topics: Amygdala & Fear conditioning. The author has an hindex of 18, co-authored 30 publications receiving 2542 citations. Previous affiliations of Robert M. Sears include Nathan Kline Institute for Psychiatric Research & Center for Neural Science.
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Journal ArticleDOI
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Jonathan D. Hommel,Richard Trinko,Richard Trinko,Robert M. Sears,Dan Georgescu,Zong Wu Liu,Zong Wu Liu,Xiao-Bing Gao,Jeremy J. Thurmon,Michela "Micky" Marinelli,Ralph J. DiLeone,Ralph J. DiLeone +11 more
TL;DR: It is shown that VTA dopamine neurons express Lepr mRNA and respond to leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate and this data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on Vta dopamine neurons.
Journal ArticleDOI
Local gene knockdown in the brain using viral-mediated RNA interference
TL;DR: Viral-mediated RNA interference is used to generate a specific knockdown of Th, the gene encoding the dopamine synthesis enzyme tyrosine hydroxylase, within midbrain neurons of adult mice, which resulted in behavioral changes, including a motor performance deficit and reduced response to a psychostimulant.
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The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance
Dan Georgescu,Robert M. Sears,Robert M. Sears,Jonathan D. Hommel,Michel Barrot,Carlos A. Bolaños,Donald J. Marsh,Maria A. Bednarek,James A. Bibb,Eleftheria Maratos-Flier,Eric J. Nestler,Ralph J. DiLeone,Ralph J. DiLeone +12 more
TL;DR: A novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists is identified and identified, suggesting that these neurons are responsive to a specific set of physiologically relevant conditions.
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The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
TL;DR: In this article, defensive reactions (freezing), actions (avoidance) and habits (habitual avoidance) are viewed as being controlled by unique circuits that operate nonconsciously in the control of behavior, and that are distinct from the circuits that give rise to conscious feelings of fear and anxiety.
Journal ArticleDOI
Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus
Robert M. Sears,Ann E. Fink,Mattis B. Wigestrand,Mattis B. Wigestrand,Claudia R. Farb,Luis de Lecea,Joseph E. LeDoux,Joseph E. LeDoux +7 more
TL;DR: It is shown that orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning, specifically during the aversive event.