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Robert M. Shih

Researcher at Lawrence Berkeley National Laboratory

Publications -  4
Citations -  605

Robert M. Shih is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Gene & Insertional mutagenesis. The author has an hindex of 2, co-authored 4 publications receiving 556 citations.

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Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

TL;DR: Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that the cAMP-protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.
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A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana.

TL;DR: CPSFL1 appears to be an example of a eukaryotic cytosolic protein that has been coopted for a function in the chloroplast, an organelle derived from endosymbiosis of a cyanobacterium, and potentially facilitates vesicle formation by trafficking PA and/or PIP, known regulators of membrane trafficking between organellar subcompartments.
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Discovery of photosynthesis genes through whole-genome sequencing of acetate-requiring mutants of Chlamydomonas reinhardtii.

TL;DR: In this article, the authors sequenced the genomes of 660 Chlamydomonas reinhardtii acetate-requiring mutants, part of a larger photosynthesis mutant collection previously generated by insertional mutagenesis with a linearized plasmid.