M
Mary Elizabeth Bach
Researcher at Columbia University
Publications - 6
Citations - 3309
Mary Elizabeth Bach is an academic researcher from Columbia University. The author has contributed to research in topics: Long-term potentiation & Hippocampus. The author has an hindex of 6, co-authored 6 publications receiving 3183 citations. Previous affiliations of Mary Elizabeth Bach include Howard Hughes Medical Institute.
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Journal ArticleDOI
Control of memory formation through regulated expression of a CaMKII transgene
TL;DR: A forebrain-specific promoter was combined with the tetracycline transactivator system to achieve both regional and temporal control of transgene expression, and the CaMKII signaling pathway is critical for both explicit and implicit memory storage.
Journal ArticleDOI
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.
Mary Elizabeth Bach,Mark Barad,Hyeon Son,Min Zhuo,Yun Fei Lu,Robert M. Shih,Isabelle M. Mansuy,Robert D. Hawkins,Eric R. Kandel +8 more
TL;DR: Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that the cAMP-protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.
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Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency
TL;DR: It is found that transgenic mice could not learn to navigate to a specific location using spatial cues in contextual fear conditioning, and this dissociation between spatial and contextual memory suggests that even though both require the hippocampus, they may be mediated by different synaptic mechanisms.
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Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.
TL;DR: Behavioral results suggest that calcineurin has a role in the transition from short- to long-term memory, which correlates with a novel intermediate phase of LTP.
Journal ArticleDOI
Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways
Yan-You Huang,Mary Elizabeth Bach,Hans-Peter Lipp,Min Zhuo,David P. Wolfer,Robert D. Hawkins,Luc Schoonjans,Eric R. Kandel,Jean-Marie Godfraind,Richard C. Mulligan,D. Collen,Peter Carmeliet +11 more
TL;DR: Genetic evidence is provided that t-PA is a downstream effector gene important for L-LTP and that modest impairment of L- LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes.