R
Robert R. MacGregor
Researcher at Brookhaven National Laboratory
Publications - 101
Citations - 10112
Robert R. MacGregor is an academic researcher from Brookhaven National Laboratory. The author has contributed to research in topics: Human brain & Monoamine oxidase B. The author has an hindex of 45, co-authored 101 publications receiving 9770 citations.
Papers
More filters
Journal ArticleDOI
Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects
Jean Logan,Joanna S. Fowler,Nora D. Volkow,Alfred P. Wolf,Stephen L. Dewey,David J. Schlyer,Robert R. MacGregor,Robert Hitzemann,Bernard Bendriem,S. John Gatley,David R. Christman +10 more
TL;DR: It can be shown that, for many systems, linearity is effectively reached some time before this, and this method provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects.
Journal ArticleDOI
Inhibition of monoamine oxidase B in the brains of smokers
Joanna S. Fowler,Nora D. Volkow,Nora D. Volkow,Gene-Jack Wang,N. Pappas,Jean Logan,Robert R. MacGregor,David Alexoff,Colleen Shea,David J. Schlyer,Alfred P. Wolf,Donald Warner,I. Zezulkova,R. Cilento +13 more
TL;DR: It is proposed that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.
Journal Article
Metabolic trapping as a principle of oradiopharmaceutical design: some factors resposible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose.
Brian M. Gallagher,Joanna S. Fowler,Neal I. Gutterson,Robert R. MacGregor,C.N. Wan,Alfred P. Wolf +5 more
TL;DR: The rapid excretion of F-18-DG from liver, lungs and kidneys, and the retention by the heart and brain, is the result of metabolic trapping within certain organs and is reflective of glucose utilization.
Journal ArticleDOI
A Fluorinated Glucose Analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic Tracer for Rapid Tumor Detection
Peter M. Som,Harold L. Atkins,D Bandoypadhyay,Joanna S. Fowler,Robert R. MacGregor,K. Matsui,Z.H. Oster,D.F. Sacker,Chyng-Yann Shiue,H Turner,C.N. Wan,Alfred P. Wolf,S V Zabinski +12 more
TL;DR: Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals, and a scintiscan of a seminoma in a dog showed very high uptake in the viable part and lack of uptake inThe necrotic mass.
Journal ArticleDOI
Glucose metabolic rate kinetic model parameter determination in humans: the lumped constants and rate constants for [18F]fluorodeoxyglucose and [11C]deoxyglucose.
Martin Reivich,Abass Alavi,Alfred P. Wolf,Joanna S. Fowler,J.A.G. Russell,Carroll D. Arnett,Robert R. MacGregor,Chyng-Yann Shiue,Harold L. Atkins,A. Anand,R. Dann,Joel H. Greenberg +11 more
TL;DR: Using the rate constants and lumped constants determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 mg/100 g/min, respectively.