Carroll D. Arnett

TL;DR: Using the rate constants and lumped constants determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 ± 0.37 (n = 6) and 4.99 mg/100 g/min, respectively.

TL;DR: Suicide enzyme inactivators labeled with positron emitters can be used to quantitate the distribution and kinetic characteristics of MAO in human brain structures and show rapid clearance of the inactive enantiomer and retention of the active enantiomers within MAO B-rich brain structures.

TL;DR: Uptake and clearance of 18F-NMS in cerebellar tissue was not appreciably affected by antipsychotic medication or drug withdrawal, and an inverse relation between labeled competitor uptake and drug plasma level has been demonstrated.

TL;DR: The distribution of carbon‐11‐labeled L‐deprenyl, an irreversible inhibitor of monoamine oxidase type B (MAO‐B), was determined in the baboon brain by positron emission tomography and the half‐life for turnover was determined to be 30 days.

TL;DR: Analysis of the metabolic stability of the radioactively labeled compound in rat striatum indicated that greater than 95% of [18F]spiroperidol remains unchanged after 4 h, suggesting that spiro peridol either has a very slow dissociation rate or that it binds irreversibly to these receptors in vivo.