Journal ArticleDOI
A Fluorinated Glucose Analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic Tracer for Rapid Tumor Detection
Peter M. Som,Harold L. Atkins,D Bandoypadhyay,Joanna S. Fowler,Robert R. MacGregor,K. Matsui,Z.H. Oster,D.F. Sacker,Chyng-Yann Shiue,H Turner,C.N. Wan,Alfred P. Wolf,S V Zabinski +12 more
TLDR
Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals, and a scintiscan of a seminoma in a dog showed very high uptake in the viable part and lack of uptake inThe necrotic mass.Abstract:
Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals. The tumor uptake reached a peak by 30 min and remained relatively constant up to 60 min, with a very slow wash-out of F-18 activity from the tumor thereafter. Tumor-to-normal tissue and tumor-to-blood ratios ranged from 2.10-9.15 and 2.61-17.82, respectively, depending on the type of tumor. A scintiscan of a seminoma in a dog showed very high uptake in the viable part and lack of uptake in the necrotic mass. Toxicological studies in mice using 1000 times human tracer dose (HTD) per wk for 3 wk and in dogs using 50 times HTD per wk for 3 wk did not show any evidence of acute or chronic toxicity.read more
Citations
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The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Targeting metabolic transformation for cancer therapy
TL;DR: This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.
Journal ArticleDOI
Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography
G. Di Chiro,R L DeLaPaz,Rodney A. Brooks,L. Sokoloff,Paul L. Kornblith,Barry H. Smith,Nicholas J. Patronas,Conrad V. Kufta,R. M. Kessler,Gerald S. Johnston,R. G. Manning,Alfred P. Wolf +11 more
TL;DR: A correlation between rate of glycolysis and malignancy in primary cerebral tumors is found and Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.
Journal ArticleDOI
Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study
Raya S. Brown,Richard L. Wahl +1 more
TL;DR: The mechanism of glucose entry into these tumors is not well understood, but it is clear that higher than normal glucose metabolism in breast cancers is a cause for concern.
Journal ArticleDOI
Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis.
Steven M. Larson,Yusuf E. Erdi,Tim Akhurst,Madhu Mazumdar,Homer A. Macapinlac,Ronald D. Finn,Cecille Casilla,Melissa Fazzari,NC Srivastava,Henry W.D. Yeung,John L. Humm,Jose G. Guillem,Robert J. Downey,Martin S. Karpeh,Alfred E. Cohen,Robert J. Ginsberg +15 more
TL;DR: The findings set the stage for validation studies of the VRS and deltaTLG as objective measures of clinical treatment response, through comparison to the appropriate gold standards of posttreatment histopathology, recurrence free survival, and disease specific survival in well characterized populations of patients with locally advanced cancers.
References
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Journal Article
Influence of glucose antimetabolites on the Walker tumor.
TL;DR: The modified metabolic environment created by the presence of 2DG was rather quickly changed after cessation of administration, with resumption of tumor growth to a rate approaching that of controls.