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Robert V. Farese
Researcher at Harvard University
Publications - 484
Citations - 54181
Robert V. Farese is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin & Protein kinase C. The author has an hindex of 115, co-authored 473 publications receiving 48754 citations. Previous affiliations of Robert V. Farese include University of South Florida & University at Buffalo.
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Journal ArticleDOI
Comparison of changes in inositide and noninositide phospholipids during acute and prolonged adrenocorticotropic hormone treatment in vivo.
Journal ArticleDOI
Effects of ACTH on Adrenal RNA Synthesis1
Robert V. Farese,Joel J. Schnure +1 more
TL;DR: ACTH administration enhances the activity of adrenal homogenates and purified nuclei for incorporation of ATP-14C and UTP-3H into RNA, suggesting a requirement for newly synthesized protein in this action of ACTH.
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Insulin treatment acutely increases the concentration of phosphatidylserine in rat adipose tissue.
TL;DR: Insulin treatment in vivo or in vitro for 60 min elicited 40 and 35% increases, respectively, in phosphati-dylserine concentration in rat adipose tissue, which may contribute to known effects of insulin on pyruvate dehydrogenase, low K m phosphodiesterase and, perhaps, other enzymes.
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ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo.
TL;DR: It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.
Journal ArticleDOI
Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.
Hubert Chen,Robert V. Farese +1 more
TL;DR: The inactivation of enzymes in the anabolic process of fatty acid uptake and storage is more likely to enhance tissue glucose disposal or insulin secretion, whereas disruptions in the catabolic process tend to impair insulin action or secretion.