R
Robert V. Farese
Researcher at Harvard University
Publications - 484
Citations - 54181
Robert V. Farese is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin & Protein kinase C. The author has an hindex of 115, co-authored 473 publications receiving 48754 citations. Previous affiliations of Robert V. Farese include University of South Florida & University at Buffalo.
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Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
TL;DR: The genes encoding two DGAT enzymes, DGAT1 and DGAT2, were identified in the past decade, and the use of molecular tools, including mice deficient in either enzyme, has shed light on their functions.
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Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
TL;DR: Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology.
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Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
Sylvaine Cases,S. Stone,Ping Zhou,Eric Yen,Bryan Tow,Kathryn D. Lardizabal,Toni Voelker,Robert V. Farese +7 more
TL;DR: A second mammalian DGAT, DGAT2, is cloned and characterized, which was identified by its homology to a DGAT in the fungus Mortierella rammaniana, suggesting that it may play a significant role in mammalian triglyceride metabolism.
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The biophysics and cell biology of lipid droplets
TL;DR: The regulation of the composition of the phospholipid surfactants at the surface of lipid droplets is crucial for lipid droplet homeostasis and protein targeting to their surfaces.
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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Matthew D. Hirschey,Tadahiro Shimazu,Enxuan Jing,Carrie A. Grueter,Amy M. Collins,Bradley E. Aouizerat,Alena Stančáková,Eric S. Goetzman,Maggie Lam,Bjoern Schwer,Robert Stevens,Michael J. Muehlbauer,Sanjay Kakar,Nathan M. Bass,Johanna Kuusisto,Markku Laakso,Frederick W. Alt,Frederick W. Alt,Christopher B. Newgard,Robert V. Farese,C. Ronald Kahn,Eric Verdin +21 more
TL;DR: It is found that high-fat diet (HFD) feeding induces hepatic mitochondrial protein hyperacetylation in mice and downregulation of the major mitochondrial protein deacetylase SIRT3, which contributes to the metabolic syndrome.