R
Robert V. Farese
Researcher at Harvard University
Publications - 484
Citations - 54181
Robert V. Farese is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin & Protein kinase C. The author has an hindex of 115, co-authored 473 publications receiving 48754 citations. Previous affiliations of Robert V. Farese include University of South Florida & University at Buffalo.
Papers
More filters
Journal ArticleDOI
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B. Lombard,Frederick W. Alt,Hwei Ling Cheng,Jakob Bunkenborg,Ryan S. Streeper,Raul Mostoslavsky,Jennifer Kim,George D. Yancopoulos,David M. Valenzuela,Andrew J. Murphy,Yinhua Yang,Yaohui Chen,Matthew D. Hirschey,Roderick T. Bronson,Marcia C. Haigis,Leonard Guarente,Robert V. Farese,Sherman M. Weissman,Eric Verdin,Bjoern Schwer,Bjoern Schwer +20 more
TL;DR: It is demonstrated that SIRT3 has evolved to control reversible lysine acetylation in this organelle and is shown to be a soluble mitochondrial protein.
Journal ArticleDOI
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Sylvaine Cases,Steven J. Smith,Yaowu Zheng,Heather M. Myers,Steven R. Lear,Eric Sande,Sabine Novak,Colin Collins,Carrie B. Welch,Aldons J. Lusis,Sandra K. Erickson,Robert V. Farese +11 more
TL;DR: An expressed sequence tag clone that shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fatty acyl coA as a substrate was identified, which will greatly facilitate studies of cellular glycerolipid metabolism and its regulation.
Journal ArticleDOI
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
Landin Boring,Jennifa Gosling,Stephen W. Chensue,Steven L. Kunkel,Robert V. Farese,Hal E. Broxmeyer,Israel F. Charo +6 more
TL;DR: It is concluded that CCR2-/- mice have significant defects in both delayed-type hypersensitivity responses and production of Th1-type cytokines, suggesting an important and unexpected role for C CR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation.
Journal ArticleDOI
A dual thrombin receptor system for platelet activation
Mark L. Kahn,Yaowu Zheng,Wei Huang,Violeta Bigornia,Dewan Zeng,Stephen Moff,Robert V. Farese,Carmen Tam,Shaun R. Coughlin +8 more
TL;DR: It is reported that thrombin responses in platelets from PAR3-deficient mice were markedly delayed and diminished but not absent, and the identification of a two-receptor system for platelet activation byThrombin has important implications for the development of antithrombotic therapies.
Journal ArticleDOI
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Steven J. Smith,Sylvaine Cases,Dalan R. Jensen,Hubert Chen,Eric Sande,Bryan Tow,David A. Sanan,Jacob Raber,Robert H. Eckel,Robert V. Farese +9 more
TL;DR: It is shown that Dgat-deficient (Dgat−/−) mice are viable and can still synthesize triglycerides, and these mice are lean and resistant to diet-induced obesity.