P
Paul Van Eerdewegh
Researcher at Harvard University
Publications - 40
Citations - 5679
Paul Van Eerdewegh is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Pharmacogenomics. The author has an hindex of 22, co-authored 40 publications receiving 5535 citations. Previous affiliations of Paul Van Eerdewegh include Washington University in St. Louis & Massachusetts Mental Health Center.
Papers
More filters
Journal ArticleDOI
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
Randall D. Little,John P. Carulli,Richard G. Del Mastro,Josée Dupuis,Mark Osborne,Colleen Folz,Susan P. Manning,Pamela Marie Swain,Shan Chuan Zhao,Brenda K. Eustace,Michelle M. Lappe,Lia Spitzer,Susan Zweier,Karen Braunschweiger,Youssef Benchekroun,Xintong Hu,Ronald Adair,Linda Chee,Michael Fitzgerald,Craig Tulig,Anthony Caruso,Nia Tzellas,Alicia Bawa,Barbara Franklin,Shannon M. McGuire,Shannon M. McGuire,Xavier Nogués,Xavier Nogués,Gordon Gong,Kristina Allen,Anthony Anisowicz,Arturo Morales,Peter T. Lomedico,Susan M. Recker,Paul Van Eerdewegh,Robert R. Recker,Mark L. Johnson +36 more
TL;DR: It is suggested that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis.
Journal ArticleDOI
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Paul Van Eerdewegh,Randall D. Little,Josée Dupuis,Richard G. Del Mastro,Kathy Falls,Jason Simon,Dana Torrey,Sunil Pandit,Joyce McKenny,Karen Braunschweiger,Alison Walsh,Ziying Liu,Brooke Hayward,Colleen Folz,Susan P. Manning,Alicia Bawa,Lisa Saracino,Michelle Thackston,Youssef Benchekroun,Neva J. Capparell,Mei Wang,Ron Adair,Yun Feng,Joann Dubois,Michael Fitzgerald,Hui Huang,Rene Gibson,Kristina Allen,Alex Pedan,Melvyn R. Danzig,Shelby P. Umland,Robert W. Egan,Cuss Francis M,S. Rorke,Joanne B. Clough,John W. Holloway,Stephen T. Holgate,Tim Keith +37 more
TL;DR: In this article, the authors performed a genome-wide scan on 460 Caucasian families and identified a locus on chromosome 20p13 that was linked to asthma (log 10 of the likelihood ratio (LOD), 2.94 and bronchial hyperresponsiveness (LOD, 3.93).
Journal ArticleDOI
Genome‐wide search for genes affecting the risk for alcohol dependence
Theodore Reich,Howard J. Edenberg,Alison Goate,Jeff T. Williams,John P. Rice,Paul Van Eerdewegh,Tatiana Foroud,Victor Hesselbrock,Marc A. Schuckit,Kathleen K. Bucholz,Bernice Porjesz,Ting-Kai Li,P. Michael Conneally,John I. Nurnberger,Jay A. Tischfield,Raymond R. Crowe,C. Robert Cloninger,William Wu,Shantia Shears,Kristie Carr,Candice Crose,Chris Willig,Henri Begleiter +22 more
TL;DR: There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
Journal ArticleDOI
Screening large-scale association study data: exploiting interactions using random forests
TL;DR: In the context of large-scale genetic association studies where unknown interactions exist among true risk-associated SNPs or SNPs and environmental covariates, screening SNPs using random forest analyses can significantly reduce the number of SNPs that need to be retained for further study compared to standard univariate screening methods.
Journal ArticleDOI
Identifying SNPs predictive of phenotype using random forests.
Alexandre Bureau,Josée Dupuis,Kathleen Falls,Kathryn L. Lunetta,Brooke Hayward,Tim Keith,Paul Van Eerdewegh +6 more
TL;DR: This work extends the concept of importance to pairs of predictors, to capture joint effects, and explores the behavior of importance measures over a range of two‐locus disease models in the presence of a varying number of SNPs unassociated with the phenotype.