R
Robert W. Hsieh
Researcher at Stanford University
Publications - 16
Citations - 1274
Robert W. Hsieh is an academic researcher from Stanford University. The author has contributed to research in topics: Triple-negative breast cancer & Cancer. The author has an hindex of 10, co-authored 15 publications receiving 802 citations. Previous affiliations of Robert W. Hsieh include University of Chicago.
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Journal ArticleDOI
Single-cell transcriptional diversity is a hallmark of developmental potential.
Gunsagar S. Gulati,Shaheen S. Sikandar,Daniel J. Wesche,Anoop Manjunath,Anjan Bharadwaj,Mark J. Berger,Francisco Ilagan,Angera H. Kuo,Robert W. Hsieh,Shang Cai,Maider Zabala,Ferenc A. Scheeren,Neethan A. Lobo,Dalong Qian,Feiqiao Brian Yu,Frederick M. Dirbas,Michael F. Clarke,Aaron M. Newman +17 more
TL;DR: A simple, yet robust, determinant of developmental potential—the number of expressed genes per cell—is demonstrated and leverage this measure of transcriptional diversity to develop a computational framework (CytoTRACE) for predicting differentiation states from scRNA-seq data.
Journal ArticleDOI
High-speed tapping mode imaging with active Q control for atomic force microscopy
Todd Sulchek,Robert W. Hsieh,J. D. Adams,Goksen G. Yaralioglu,Stephen C. Minne,Calvin F. Quate,Jason Cleveland,Abdullah Atalar,Dennis M. Adderton +8 more
TL;DR: In this article, a ZnO piezoelectric cantilever was used for high-speed AFM imaging with an order of magnitude increase in mechanical bandwidth and active damping.
Journal ArticleDOI
Primary analysis of a randomized, double-blind, phase II study of the anti-TIGIT antibody tiragolumab (tira) plus atezolizumab (atezo) versus placebo plus atezo as first-line (1L) treatment in patients with PD-L1-selected NSCLC (CITYSCAPE).
Delvys Rodriguez-Abreu,Melissa Lynne Johnson,Maen A. Hussein,Manuel Cobo,Anjan Jayantilal Patel,Nevena Milica Secen,Ki Hyeong Lee,Bartomeu Massuti,Sandrine Hiret,James Chih-Hsin Yang,Fabrice Barlesi,Dae Ho Lee,Luis Paz-Ares,Robert W. Hsieh,Karen Miller,Namrata Patil,Patrick Twomey,Amy V. Kapp,Raymond D. Meng,Byoung Chul Cho +19 more
TL;DR: The immunomodulatory receptor TIGIT is a novel inhibitory immune checkpoint present on activated T cells and NK cells in multiple cancers, including NSCLC, and in a phase I study it is proposed that this checkpoint acts as an “inhibitory checkpoint” to halt cell reprograming.
Journal ArticleDOI
High-speed atomic force microscopy in liquid
Todd Sulchek,Robert W. Hsieh,J. D. Adams,Stephen C. Minne,Calvin F. Quate,Dennis M. Adderton +5 more
TL;DR: In this article, the authors used a standard optical lever AFM and a cantilever with an integrated zinc oxide (ZnO) piezoelectric actuator for high-speed constant force imaging in liquid.
Journal ArticleDOI
Tiragolumab plus atezolizumab versus placebo plus atezolizumab as a first-line treatment for PD-L1-selected non-small-cell lung cancer (CITYSCAPE): primary and follow-up analyses of a randomised, double-blind, phase 2 study.
Byoung Chul Cho,Delvys Rodriguez Abreu,Maen A. Hussein,Manuel Cobo,Anjan Jayantilal Patel,Nevena Secen,Ki Hyeong Lee,Bartomeu Massuti,Sandrine Hiret,James Chih-Hsin Yang,Fabrice Barlesi,Dae Ho Lee,L. Arés,Robert W. Hsieh,Namrata Patil,P E Twomey,Xiaoying Yang,Raymond D. Meng,Melissa Lynne Johnson +18 more
TL;DR: Tiragolumab plus atezolizumab (anti-PD-L1) therapy was used as first-line treatment for non-small-cell lung cancer (NSCLC) as discussed by the authors .