Shang Cai

TL;DR: A simple, yet robust, determinant of developmental potential—the number of expressed genes per cell—is demonstrated and leverage this measure of transcriptional diversity to develop a computational framework (CytoTRACE) for predicting differentiation states from scRNA-seq data.

TL;DR: Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.

TL;DR: This work shows that mutation of the nuclear localization signal (NLS) of human Kinesin-14 HSET caused an accumulation of HSET in the cytoplasm, which resulted in strong microtubule bundling and changes in spindle length, consistent with a model in which Ran regulates the association of Kines in-14s with importin alpha/beta to prevent aberrant cross-linking and bundling of microtubules by sequestering KinesIn-14

TL;DR: In this article , the authors explored the functional significance of these intratumor bacteria, primarily using a murine spontaneous breast-tumor model MMTV-PyMT, and found that depletion of intratumors significantly reduced lung metastasis without affecting primary tumor growth.

TL;DR: This study reports that miR-142 efficiently recruits the APC mRNA to an RNA-induced silencing complex, activates the canonical WNT signaling pathway in an APC-suppression dependent manner, and activates the expression ofmiR-150.