Feiqiao Brian Yu

TL;DR: A simple, yet robust, determinant of developmental potential—the number of expressed genes per cell—is demonstrated and leverage this measure of transcriptional diversity to develop a computational framework (CytoTRACE) for predicting differentiation states from scRNA-seq data.

TL;DR: In this paper, a 17-week randomized, prospective study (n = 18/arm) combined with -omics measurements of microbiome and host, including extensive immune profiling, was conducted to determine how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence the human microbiome and immune system in healthy adults.

TL;DR: This article used a 17-week randomized, prospective study design combined with -omics measurements of microbiome and host, including extensive immune profiling, to determine how each diet affects the human microbiome and immune system in healthy adults.

TL;DR: Human microbiotas were remarkably resilient and recovered during antibiotic treatment, with transient dominance of resistant Bacteroides and taxa-asymmetric diversity reduction, and translational potential for modulating diet, sanitation, and microbiota composition during antibiotics.

TL;DR: The discovery of a complete and divergent hydrogenotrophic methanogenesis pathway in a thermophilic order of the Verstraetearchaeota is reported, which is named Candidatus Methanohydrogenales, as well as the presence of the WLP in the crenarchaeal order Desulfurococcales.