R
Robert W. Myers
Researcher at Merck & Co.
Publications - 63
Citations - 7661
Robert W. Myers is an academic researcher from Merck & Co.. The author has contributed to research in topics: Histone deacetylase & Apicidin. The author has an hindex of 24, co-authored 61 publications receiving 7011 citations. Previous affiliations of Robert W. Myers include Johns Hopkins University & Southern Illinois University Carbondale.
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Journal ArticleDOI
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus
Jiayi Xu,Songnian Lin,Robert W. Myers,George H. Addona,Joel P. Berger,Brian T. Campbell,Hsuan-shen Chen,Zhesheng Chen,George J. Eiermann,Nadine Elowe,Brian T. Farrer,Wen Feng,Qinghong Fu,Roman Kats-Kagan,Michael Kavana,Sunita Malkani,Daniel R. McMasters,Kaushik Mitra,Michele Pachanski,Xinchun Tong,Maria E. Trujillo,Libo Xu,Bei Zhang,Fengqi Zhang,Rui Zhang,Emma R. Parmee +25 more
TL;DR: The design, synthesis, and biological evaluation of a novel series of 2,5,6-trisubstituted indole derivatives that act as highly potent GKAs are reported, found to possess high in vitro potency, excellent physicochemical properties, and good pharmacokinetic profile in rodents.
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Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance
Jian Liu,Joseph Kelly,Wensheng Yu,Dane Clausen,Younong Yu,Hyunjin M. Kim,Joseph L. Duffy,Christine C. Chung,Robert W. Myers,Steve S. Carroll,Daniel J. Klein,James I. Fells,M. Katharine Holloway,Jin Wu,Guoxin Wu,Bonnie J. Howell,Richard J. O. Barnard,Joseph A. Kozlowski +17 more
TL;DR: A series of selective and potent class I HDAC inhibitors based on aryl ketones as a zinc binding group, which reversed HIV latency using a Jurkat model of HIV latency in 2C4 cells are reported.
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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Wensheng Yu,Jian Liu,Younong Yu,Vivian Zhang,Dane Clausen,Joseph Kelly,Scott E. Wolkenberg,Douglas C. Beshore,Joseph L. Duffy,Christine C. Chung,Robert W. Myers,Daniel J. Klein,James I. Fells,Kate Holloway,Jin Wu,Guoxin Wu,Bonnie J. Howell,Richard J. O. Barnard,Joseph A. Kozlowski +18 more
TL;DR: A novel series of ethyl ketone basedHDACs 1, 2, and 3 selective inhibitors have been identified with good enzymatic and cellular activity and high selectivity over HDACs 6 and 8, which contain a spirobicyclic group in the amide region.
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A Randomized Trial of Telbivudine (LdT) vs Adefovir for HBeAg-positive Chronic Hepatitis B: Final Week 52 results
Natalie Bzowej,Hly Chan,Ching-Lung Lai,Mong Cho,Y.-M. Moon,You-Chen Chao,EJ Heathcote,Robert W. Myers,Gerald Y. Minuk,Patrick Marcellin,Lennox J. Jeffers,William Sievert,Ralf Kaiser,George Harb,G. Chao,Nathaniel A. Brown +15 more
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Effect of alpha-D-mannopyranosylmethyl-p-nitrophenyltriazene on hepatic degradation and processing of the N-linked oligosaccharide chains of alpha 1-acid glycoprotein.
TL;DR: Since alpha-ManMNT is likely to irreversibly inactivate alpha-D-mannosidases, the return of normal AGP secretory forms after 24 h probably resulted from synthesis of new processing enzymes.