Joseph L. Duffy

TL;DR: In this article, the authors investigated the direction and degree of stereoselectivity in aldol addition reactions involving achiral unsubstituted metal enolate and enolsilane nucleophiles and chiral aldehydes.

TL;DR: It is demonstrated that chronic inhibition of OGA reduces pathological t Tau in the brain and total tau in the CSF of rTg4510 mice, most likely by directly increasing O-GlcNAcylation of tau and thereby maintaining tauIn the soluble, non-toxic form by reducing tau aggregation and the accompanying panoply of deleterious post-translational modifications.

TL;DR: In this article, the authors proposed phenylalanine derivatives which are inhibitors of the dipeptidyl peptidyl enzyme-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the PD enzyme is involved.

TL;DR: Compound 1 (Cpd 1) is a potent glucagon receptor antagonist that has the capability to block the effects of glucagon in vivo, and real-time measurement of glycogen synthesis and breakdown in perfused mouse liver showed that Cpd 1 is capable of blocking glucagon-induced glycogenolysis in a dosage-dependent manner.

TL;DR: In this article, a model for 1,3-asymmetric induction for polar addition processes such as the Mukaiyama aldol reaction is proposed to account for the documented trends in reaction diastereoselection for polar β-substituents.