R
Robert W. Myers
Researcher at Merck & Co.
Publications - 63
Citations - 7661
Robert W. Myers is an academic researcher from Merck & Co.. The author has contributed to research in topics: Histone deacetylase & Apicidin. The author has an hindex of 24, co-authored 61 publications receiving 7011 citations. Previous affiliations of Robert W. Myers include Johns Hopkins University & Southern Illinois University Carbondale.
Papers
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Journal ArticleDOI
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
Anthony Ogawa,Christopher A. Willoughby,Raynald Bergeron,Kenneth P. Ellsworth,Wayne M. Geissler,Robert W. Myers,Jun Yao,Georgianna Harris,Kevin T. Chapman +8 more
TL;DR: The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented and SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.
Journal ArticleDOI
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Peter T. Meinke,Steven L. Colletti,George A. Doss,Robert W. Myers,Anne Gurnett,Paula M. Dulski,Sandra J. Darkin-Rattray,John J. Allocco,Stefan Galuska,Dennis M. Schmatz,Matthew J. Wyvratt,Michael H. Fisher +11 more
TL;DR: The new quinolones exhibited good parasite selectivity and potency both at the level of their molecular target, histone deacetylase, and in their whole cell antiproliferative activity in vitro.
Patent
Histone deacetylase as target for antiprotozoal agents
TL;DR: In this article, Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds, which is useful as therapeutic agents against protozoal infections.
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N-Substituted (β-d-galactopyranosylmethyl)amines, and C-β-d-galactopyranosylformamides, and related compounds
TL;DR: A series of N -substituted (β-d -galactopyranosylmethyl)amines, a series of β-d-galactopyrosyl cyanide compounds have been synthesized and characterized.
Journal ArticleDOI
Genetic diversity and virulence profiles of Listeria monocytogenes recovered from bulk tank milk, milk filters, and milking equipment from dairies in the United States (2002 to 2014).
Seon Woo Kim,Julie Haendiges,Eric N. Keller,Robert W. Myers,A. Kim,Jason E. Lombard,Jeffrey S. Karns,Jo Ann S. Van Kessel,Bradd J. Haley +8 more
TL;DR: There is a high level of genetic diversity among the L. monocytogenes present in bulk tank milk in the United States with some strains being more frequently detected than others, and some being similar to those that have been isolated from previous non-dairy related outbreaks.