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Roberta Brambilla
Researcher at University of Miami
Publications - 62
Citations - 3096
Roberta Brambilla is an academic researcher from University of Miami. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Tumor necrosis factor alpha. The author has an hindex of 23, co-authored 52 publications receiving 2445 citations. Previous affiliations of Roberta Brambilla include University of Southern Denmark & Miami Project to Cure Paralysis.
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Journal ArticleDOI
Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury
Roberta Brambilla,Valerie Bracchi-Ricard,Wenhui Hu,Beata Frydel,Annmarie Bramwell,Shaffiat Karmally,Edward J. Green,John R. Bethea,John R. Bethea +8 more
TL;DR: It is demonstrated that selective inactivation of astroglial NF-κB in transgenic mice expressing a dominant negative (dn) form of the inhibitor of κBα under the control of an astrocyte-specific promoter leads to a dramatic improvement in functional recovery 8 wk after contusive spinal cord injury (SCI).
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Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation.
Roberta Brambilla,Trikaldarshi Persaud,Xianchen Hu,Shaffiat Karmally,Valery I. Shestopalov,Galina Dvoriantchikova,Dmitry Ivanov,Lubov Nathanson,Scott R. Barnum,John R. Bethea +9 more
TL;DR: It is shown that transgenic inactivation of astroglial NF-κB (glial fibrillary acidic protein-IκBα-dominant-negative mice) resulted in reduced disease severity and improved functional recovery following experimental autoimmune encephalomyelitis, directly implicating astrocytes in the pathophysiology of this disease.
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Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination.
Roberta Brambilla,Jessica Jopek Ashbaugh,Jessica Jopek Ashbaugh,Roberta Magliozzi,Anna Dellarole,Shaffiat Karmally,David E. Szymkowski,John R. Bethea,John R. Bethea +8 more
TL;DR: It is demonstrated that selective inhibition of soluble tumour necrosis factor improves recovery following experimental autoimmune encephalomyelitis, and that signalling mediated by transmembrane tumour Necrosis factor is essential for axon and myelin preservation as well as remyelination, opening the possibility of a new avenue of treatment for multiple sclerosis.
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The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
TL;DR: In this paper, a review of the current knowledge of astrocyte behavior in MS and EAE is presented, where the authors define the temporal and anatomical profile of astroglial activation, then focus on key processes they participate in.
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The mutual interplay of gut microbiota, diet and human disease
TL;DR: Interventions based on microbiome studies, that is faecal microbiota transplantation, probiotics and prebiotics, are discussed to introduce the concept that correcting gut dysbiosis can ameliorate disease symptoms, thus offering a new approach towards disease treatment.