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Roberto B. Sassi
Researcher at McMaster University
Publications - 91
Citations - 4927
Roberto B. Sassi is an academic researcher from McMaster University. The author has contributed to research in topics: Bipolar disorder & Mood disorders. The author has an hindex of 38, co-authored 83 publications receiving 4521 citations. Previous affiliations of Roberto B. Sassi include University of Pittsburgh & University of Genoa.
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Journal ArticleDOI
Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder
Emel S. Monkul,Emel S. Monkul,Emel S. Monkul,John P. Hatch,Mark Nicoletti,Susanna C. Spence,Paolo Brambilla,Acioly L.T. Lacerda,Roberto B. Sassi,Alan G. Mallinger,Matcheri S. Keshavan,Jair C. Soares,Jair C. Soares +12 more
TL;DR: Fronto-limbic anatomical brain abnormalities in suicidal and non-suicidal adult female patients with unipolar depression find abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide.
Journal ArticleDOI
Greater cortical gray matter density in lithium-treated patients with bipolar disorder
Carrie E. Bearden,Paul M. Thompson,Manish S. Dalwani,Kiralee M. Hayashi,Agatha D. Lee,Mark Nicoletti,Michael Trakhtenbroit,David C. Glahn,Paolo Brambilla,Roberto B. Sassi,Alan G. Mallinger,Ellen Frank,David J. Kupfer,Jair C. Soares,Jair C. Soares +14 more
TL;DR: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences.
Journal ArticleDOI
Increased gray matter volume in lithium-treated bipolar disorder patients
Roberto B. Sassi,Mark Nicoletti,Mark Nicoletti,Paolo Brambilla,Paolo Brambilla,Paolo Brambilla,Alan G. Mallinger,Ellen Frank,David J. Kupfer,Matcheri S. Keshavan,Jair C. Soares,Jair C. Soares +11 more
TL;DR: Total gray matter volumes were significantly increased in lithium-treated patients compared with untreated patients and healthy individuals, suggesting in vivo effects of lithium on gray matter, which could possibly reflect lithium's neurotrophic effects.
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Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression
Sheila C. Caetano,Sheila C. Caetano,Sheila C. Caetano,John P. Hatch,Paolo Brambilla,Roberto B. Sassi,Mark Nicoletti,Alan G. Mallinger,Ellen Frank,David J. Kupfer,Matcheri S. Keshavan,Jair C. Soares,Jair C. Soares +12 more
TL;DR: The finding of smaller hippocampi in currently depressed patients is consistent with the hypothesis that hypercortisolism could result in hippocampal neurotoxicity in major depression and a smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients.
Journal ArticleDOI
MRI investigation of temporal lobe structures in bipolar patients.
Paolo Brambilla,Keith Harenski,Mark Nicoletti,Mark Nicoletti,Roberto B. Sassi,Roberto B. Sassi,Alan G. Mallinger,Ellen Frank,David J. Kupfer,Matcheri S. Keshavan,Jair C. Soares,Jair C. Soares +11 more
TL;DR: The findings of enlarged left amygdala in bipolar patients are in agreement with prior MRI studies, suggesting that abnormalities in this brain structure may be implicated in pathophysiology of the illness.