抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

We present an overview of the lattice Boltzmann method (LBM), a parallel and efficient algorithm for simulating single-phase and multiphase fluid flows and for incorporating additional physical complexities. The LBM is especially useful for modeling complicated boundary conditions and multiphase interfaces. Recent extensions of this method are described, including simulations of fluid turbulence, suspension flows, and reaction diffusion systems.

Lattice boltzmann method for fluid flows

The calculation of rate coefficients is a discipline of nonlinear science of importance to much of physics, chemistry, engineering, and biology. Fifty years after Kramers' seminal paper on thermally activated barrier crossing, the authors report, extend, and interpret much of our current understanding relating to theories of noise-activated escape, for which many of the notable contributions are originating from the communities both of physics and of physical chemistry. Theoretical as well as numerical approaches are discussed for single- and many-dimensional metastable systems (including fields) in gases and condensed phases. The role of many-dimensional transition-state theory is contrasted with Kramers' reaction-rate theory for moderate-to-strong friction; the authors emphasize the physical situation and the close connection between unimolecular rate theory and Kramers' work for weakly damped systems. The rate theory accounting for memory friction is presented, together with a unifying theoretical approach which covers the whole regime of weak-to-moderate-to-strong friction on the same basis (turnover theory). The peculiarities of noise-activated escape in a variety of physically different metastable potential configurations is elucidated in terms of the mean-first-passage-time technique. Moreover, the role and the complexity of escape in driven systems exhibiting possibly multiple, metastable stationary nonequilibrium states is identified. At lower temperatures, quantum tunneling effects start to dominate the rate mechanism. The early quantum approaches as well as the latest quantum versions of Kramers' theory are discussed, thereby providing a description of dissipative escape events at all temperatures. In addition, an attempt is made to discuss prominent experimental work as it relates to Kramers' reaction-rate theory and to indicate the most important areas for future research in theory and experiment.

Reaction-rate theory: fifty years after Kramers

Part I. Foundations: 1. Random variables 2. Probability measures 3. Stochastic processes 4. The stochastic integral Part II. Existence and Uniqueness: 5. Linear equations with additive noise 6. Linear equations with multiplicative noise 7. Existence and uniqueness for nonlinear equations 8. Martingale solutions Part III. Properties of Solutions: 9. Markov properties and Kolmogorov equations 10. Absolute continuity and Girsanov's theorem 11. Large time behaviour of solutions 12. Small noise asymptotic.

Stochastic Equations in Infinite Dimensions

It is shown that a dynamical system subject to both periodic forcing and random perturbation may show a resonance (peak in the power spectrum) which is absent when either the forcing or the perturbation is absent.

/pdf/the-mechanism-of-stochastic-resonance-4bzy0bizub.pdf

The mechanism of stochastic resonance

The lattice Boltzmann equation: theory and applications

We report on the existence of a hitherto undetected form of self-similarity, which we call extended self-similarity (ESS). ESS holds at high as well as at low Reynolds number, and it is characterized by the same scaling exponents of the velocity differences of fully developed turbulence.

Extended self-similarity in turbulent flows

An efficient strategy is developed for building suitable collision operators, to be used in a simplified version of the lattice gas Boltzmann equation. The resulting numerical scheme is shown to be linearly stable. The method is applied to the computation of the flow in a channel containing a periodic array of obstacles.

https://iopscience.iop.org/article/10.1209/0295-5075/9/4/008/pdf

Lattice Gas Dynamics with Enhanced Collisions

An amplification of random perturbations by the interaction of non-linearities internal to the climatic system with external, orbital forcing is found. This stochastic resonance is investigated in a highly simplified, zero-dimensional climate model. It is conceivable that this new type of resonance might play a role in explaining the 10 5 year peak in the power spectra of paleoclimatic records. DOI: 10.1111/j.2153-3490.1982.tb01787.x

https://www.tandfonline.com/doi/pdf/10.3402/tellusa.v34i1.10782

Roberto Benzi

Papers

The mechanism of stochastic resonance

The lattice Boltzmann equation: theory and applications

Extended self-similarity in turbulent flows

Lattice Gas Dynamics with Enhanced Collisions

Stochastic resonance in climatic change