R
Robin A. de Graaf
Researcher at Yale University
Publications - 130
Citations - 7957
Robin A. de Graaf is an academic researcher from Yale University. The author has contributed to research in topics: Shim (magnetism) & Nuclear magnetic resonance spectroscopy. The author has an hindex of 46, co-authored 128 publications receiving 6699 citations. Previous affiliations of Robin A. de Graaf include Utrecht University & University Medical Center Utrecht.
Papers
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Journal ArticleDOI
Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients
Douglas E. Befroy,Kitt Falk Petersen,Sylvie Dufour,Graeme F. Mason,Robin A. de Graaf,Douglas L. Rothman,Gerald I. Shulman +6 more
TL;DR: The hypothesis that insulin resistance in skeletal muscle of insulin-resistant offspring is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because of an inherited defect in the activity of mitochondrial oxidative phosphorylation is supported.
Book
In Vivo NMR Spectroscopy: Principles and Techniques
TL;DR: In this article, the authors present an overview of the basic principles of NMR, including the following: 1.1 Introduction. 2.2 Classical Description. 3.3 Quantum Mechanical Description. 4.4 Dynamic Carbon-13 NMR Spectroscopy. 5.5 Magnetic Field Gradients.
Journal ArticleDOI
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Parker L. Sulkowski,Christopher D. Corso,Nathaniel D. Robinson,Susan E. Scanlon,Karin Purshouse,Hanwen Bai,Yanfeng Liu,Ranjini K. Sundaram,Denise C. Hegan,Nathan R. Fons,Gregory A. Breuer,Yuanbin Song,Ketu Mishra-Gorur,Henk M. De Feyter,Robin A. de Graaf,Yulia V. Surovtseva,Maureen Kachman,Stephanie Halene,Murat Gunel,Peter M. Glazer,Ranjit S. Bindra +20 more
TL;DR: It is reported that IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5′-diphosphate–ribose) polymerase (PARP) inhibitors, and an unexpected link between oncometabolites, altered DNA repair, and genetic instability is uncovered.
Journal ArticleDOI
The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
Anant B. Patel,Robin A. de Graaf,Graeme F. Mason,Douglas L. Rothman,Robert G. Shulman,Kevin L. Behar +5 more
TL;DR: In isoelectric cortex, glucose oxidation was reduced >3-fold in glutamatergic and GABAergic neurons, and neurotransmitter cycling was below detection, Hence, in both cell types, the primary energetic costs are associated with neurotransmission, which increase together as cortical activity is increased.
Journal ArticleDOI
High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo.
Robin A. de Graaf,Peter B. Brown,Scott McIntyre,Terence W. Nixon,Kevin L. Behar,Douglas L. Rothman +5 more
TL;DR: While spectral resolution continues to increase with field strength, the absolute signal‐to‐noise ratio (SNR) in T1/T2‐based anatomical MRI quickly levels off beyond ∼7 T and may actually decrease at higher magnetic fields.