Robin E. Buckingham

TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.

TL;DR: Type 2 diabetic patients with apparently normal cardiac function have impaired myocardial and skeletal muscle energy metabolism related to changes in circulating metabolic substrates.

TL;DR: Treatment with rosiglitazone, previously shown to reduce insulin resistance, prevents the loss of beta-cell mass in obese ZDF rats by maintainingBeta-cell proliferation compensates for the increased beta- cell loss at a time when plasma glucose is moderately elevated, but compensation ultimately fails and the plasma glucose levels increase beyond approximately 20 mmol/l.

TL;DR: Orexin expression was not obviously related to changes in body weight, insulin, or leptin, but was stimulated under conditions of low plasma glucose in the absence of food, and may participate in the short-term regulation of energy homeostasis by initiating feeding in response to falls in glucose and terminating it after food ingestion.

TL;DR: Results demonstrate a circadian variation in feeding responses to orexin-A and an 8-day intracerebroventricular infusion with orexIn-A increased daytime feeding on days 2 and 8, but nocturnal feeding was reduced and there was no change in 24 h intake.