R
Robin E. Buckingham
Researcher at The Hertz Corporation
Publications - 35
Citations - 9345
Robin E. Buckingham is an academic researcher from The Hertz Corporation. The author has contributed to research in topics: Insulin & Leptin. The author has an hindex of 25, co-authored 35 publications receiving 8924 citations.
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Journal ArticleDOI
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more
TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
Journal ArticleDOI
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Michaela Scheuermann-Freestone,Per Lav Madsen,David Neil Manners,Andrew M. Blamire,Robin E. Buckingham,Peter Styles,George K. Radda,Stefan Neubauer,K Clarke +8 more
TL;DR: Type 2 diabetic patients with apparently normal cardiac function have impaired myocardial and skeletal muscle energy metabolism related to changes in circulating metabolic substrates.
Journal ArticleDOI
Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.
Diane T. Finegood,M. Dawn McArthur,David Kojwang,Marion J. Thomas,Brian G. Topp,Thomas Leonard,Robin E. Buckingham +6 more
TL;DR: Treatment with rosiglitazone, previously shown to reduce insulin resistance, prevents the loss of beta-cell mass in obese ZDF rats by maintainingBeta-cell proliferation compensates for the increased beta- cell loss at a time when plasma glucose is moderately elevated, but compensation ultimately fails and the plasma glucose levels increase beyond approximately 20 mmol/l.
Journal ArticleDOI
Hypothalamic orexin expression: modulation by blood glucose and feeding.
XJ Cai,Peter S. Widdowson,Joanne A. Harrold,Shelagh Wilson,Robin E. Buckingham,Jonathan R.S. Arch,Mohammad Tadayyon,John C. Clapham,John P.H. Wilding,Gareth R. Williams +9 more
TL;DR: Orexin expression was not obviously related to changes in body weight, insulin, or leptin, but was stimulated under conditions of low plasma glucose in the absence of food, and may participate in the short-term regulation of energy homeostasis by initiating feeding in response to falls in glucose and terminating it after food ingestion.
Journal ArticleDOI
Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
Andrea C. Haynes,Brian A. Jackson,Phil Overend,Robin E. Buckingham,Shelagh Wilson,Mohammad Tadayyon,Jonathan R.S. Arch +6 more
TL;DR: Results demonstrate a circadian variation in feeding responses to orexin-A and an 8-day intracerebroventricular infusion with orexIn-A increased daytime feeding on days 2 and 8, but nocturnal feeding was reduced and there was no change in 24 h intake.