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Robyn J. Law
Researcher at University of British Columbia
Publications - 4
Citations - 1225
Robyn J. Law is an academic researcher from University of British Columbia. The author has contributed to research in topics: Effector & Intimin. The author has an hindex of 4, co-authored 4 publications receiving 984 citations.
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Journal ArticleDOI
Recent Advances in Understanding Enteric Pathogenic Escherichia coli
Matthew A. Croxen,Robyn J. Law,Roland Scholz,Kristie M. Keeney,Marta Wlodarska,B. Brett Finlay +5 more
TL;DR: A comprehensive review highlights recent advances in understanding of the intestinal pathotypes of E. coli, which carry an enormous potential to cause disease and continue to present challenges to human health.
Journal ArticleDOI
In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections.
TL;DR: This work describes how EPEC and EHEC attach to host cells and subvert host-cell signaling pathways to promote infection and cause disease and suggests new therapeutic strategies to help control these significant enteric pathogens.
Journal ArticleDOI
The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300
Stephanie R. Shames,Amit P. Bhavsar,Matthew A. Croxen,Robyn J. Law,Stefanie H. C. Mak,Wanyin Deng,Yuling Li,Roza Bidshari,Carmen L. de Hoog,Leonard J. Foster,B. Brett Finlay +10 more
TL;DR: This work has identified a second target of NleC and provided the first example of a bacterial virulence factor targeting the acetyltransferase p300, and demonstrated that overexpression of p300 can antagonize repression of IL‐8 secretion by EPEC and that siRNA knock‐down of p 300 dampens IL‐ 8 secretion byEPEC ΔnleC‐infected cells.
Journal ArticleDOI
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors
Robyn J. Law,H. T. Law,Joshua M. Scurll,Roland Scholz,Andrew S. Santos,Stephanie R. Shames,Wanyin Deng,Matthew A. Croxen,Yuling Li,Carmen L. de Hoog,Joris van der Heijden,Leonard J. Foster,Julian A. Guttman,B. Brett Finlay +13 more
TL;DR: It is suggested that vesicular trafficking is a crucial cellular process that may be targeted by NleB1 and EspL through their interaction with ensconsin, and the efficacy of quantitative proteomics for identifying effector-host protein interactions is demonstrated.