Recent Advances in Understanding Enteric Pathogenic Escherichia coli
Matthew A. Croxen,Robyn J. Law,Roland Scholz,Kristie M. Keeney,Marta Wlodarska,B. Brett Finlay +5 more
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TLDR
A comprehensive review highlights recent advances in understanding of the intestinal pathotypes of E. coli, which carry an enormous potential to cause disease and continue to present challenges to human health.Abstract:
Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases. Pathogenic variants of E. coli (pathovars or pathotypes) cause much morbidity and mortality worldwide. Consequently, pathogenic E. coli is widely studied in humans, animals, food, and the environment. While there are many common features that these pathotypes employ to colonize the intestinal mucosa and cause disease, the course, onset, and complications vary significantly. Outbreaks are common in developed and developing countries, and they sometimes have fatal consequences. Many of these pathotypes are a major public health concern as they have low infectious doses and are transmitted through ubiquitous mediums, including food and water. The seriousness of pathogenic E. coli is exemplified by dedicated national and international surveillance programs that monitor and track outbreaks; unfortunately, this surveillance is often lacking in developing countries. While not all pathotypes carry the same public health profile, they all carry an enormous potential to cause disease and continue to present challenges to human health. This comprehensive review highlights recent advances in our understanding of the intestinal pathotypes of E. coli.read more
Citations
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Journal ArticleDOI
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
TL;DR: This article highlights the recent progress obtained for organisms of clinical significance, together with methodological considerations for the characterization of MDR pumps, with particular focus on AcrAB-TolC and Mex pumps.
Journal ArticleDOI
Diarrheagenic Escherichia coli.
Tânia A. T. Gomes,Waldir P. Elias,Isabel C. A. Scaletsky,Beatriz E. C. Guth,Juliana Rodrigues,Roxane M. F. Piazza,Luís Carlos de Souza Ferreira,Marina Baquerizo Martinez +7 more
TL;DR: This review has gathered information on current definitions, serotypes, lineages, virulence mechanisms, epidemiology, and diagnosis of the major diarrheagenic E. coli pathotypes.
Journal ArticleDOI
Biosensors for whole-cell bacterial detection.
TL;DR: Recent progress in the use of biosensors for the detection of whole bacterial cells for sensitive and earlier identification of bacteria without the need for sample processing is discussed, with a particular focus on electrochemical biosensing systems.
Journal ArticleDOI
Environmental Escherichia coli: ecology and public health implications—a review
Jeonghwan Jang,Hor-Gil Hur,Michael J. Sadowsky,Muruleedhara N. Byappanahalli,Tao Yan,Satoshi Ishii +5 more
TL;DR: Current knowledge on the ecology of E. coli strains in various environments with regard to its role as a faecal indicator bacterium (FIB) and as a naturalized member of indigenous microbial communities is examined.
References
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Book
Bergey's Manual of Systematic Bacteriology
TL;DR: BCL3 and Sheehy cite Bergey's manual of determinative bacteriology of which systematic bacteriology, first edition, is an expansion.
Journal ArticleDOI
Foodborne Illness Acquired in the United States—Major Pathogens
Elaine Scallan,Robert M. Hoekstra,Frederick J. Angulo,Robert V. Tauxe,Marc-Alain Widdowson,Sharon L. Roy,Jeffery L. Jones,Patricia M. Griffin +7 more
TL;DR: Each year, 31 pathogens caused 9.4 million episodes of foodborne illness, resulting in 55,961 hospitalizations and 1,351 deaths in the United States.
Journal ArticleDOI
Diarrheagenic Escherichia coli
James P. Nataro,James B. Kaper +1 more
TL;DR: The current level of understanding of the pathogenesis of the diarrheagenic E. coli strains is discussed and how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens are described.
Journal ArticleDOI
Pathogenic Escherichia coli
TL;DR: Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen.
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