W
Wanyin Deng
Researcher at University of British Columbia
Publications - 72
Citations - 6040
Wanyin Deng is an academic researcher from University of British Columbia. The author has contributed to research in topics: Effector & Citrobacter rodentium. The author has an hindex of 41, co-authored 69 publications receiving 5588 citations. Previous affiliations of Wanyin Deng include University of Washington & National Autonomous University of Mexico.
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Journal ArticleDOI
Dissecting virulence: Systematic and functional analyses of a pathogenicity island
Wanyin Deng,José L. Puente,Samantha Gruenheid,Yuling Li,Bruce A. Vallance,Alejandra Vázquez,Jeannette Barba,J. Antonio Ibarra,Paul O'Donnell,Pavel Metalnikov,Keith Ashman,Sansan Lee,David L Goode,Tony Pawson,B. Brett Finlay +14 more
TL;DR: This work systematically mutagenized all 41 CR LEE genes and functionally characterized these mutants in vitro and in a murine infection model, identifying 33 virulence factors, including two virulence regulators and a hierarchical switch for type III secretion.
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Assembly, structure, function and regulation of type III secretion systems
Wanyin Deng,Natalie C. Marshall,Jennifer L. Rowland,James M. McCoy,Liam J. Worrall,Andrew S. Santos,Natalie C. J. Strynadka,B. Brett Finlay +7 more
TL;DR: Current knowledge of the structure and function of T3SSs is summarized, which should aid mechanism-based drug design and facilitate their manipulation for biotechnological applications.
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Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.
Samantha Gruenheid,Inna Sekirov,Nikhil A. Thomas,Wanyin Deng,Paul O'Donnell,David L Goode,Yuling Li,Elizabeth A. Frey,Nathaniel Francis Brown,Pavel Metalnikov,Tony Pawson,Keith Ashman,B. Brett Finlay +12 more
TL;DR: A novel protein, NleA, encoded in a prophage‐associated pathogenicity island within the EHEC genome, distinct from the LEE was determined to play a key role in virulence of C. rodentium in a mouse infection model.
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Locus of Enterocyte Effacement from Citrobacter rodentium: Sequence Analysis and Evidence for Horizontal Transfer among Attaching and Effacing Pathogens
TL;DR: The results indicate that the full DNA sequence of C.rodentium LEE has been acquired by C. rodentium and A/E E.coli strains independently during evolution.
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Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice.
TL;DR: It is shown that Tir, but not its tyrosine phosphorylation, is essential for C. rodentium to colonize the large bowel and induce attaching/effacing (A/E) lesions and colonic hyperplasia in mice, and that both EPEC Tir and EHEC Tir can substitute for Citrobacter Tir for these activities in vivo.