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Rodrigo A. Somoza
Researcher at Case Western Reserve University
Publications - 33
Citations - 1124
Rodrigo A. Somoza is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Mesenchymal stem cell & Cartilage. The author has an hindex of 12, co-authored 30 publications receiving 719 citations. Previous affiliations of Rodrigo A. Somoza include Universidad del Desarrollo & Federico Santa María Technical University.
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Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor.
TL;DR: The first CRISPR Cas12a (cpf1) based electrochemical biosensor (E-CRISPR) is reported, which is more cost-effective and portable comparing with optical transduction based biosensing systems and could be a powerful enabler for wide developments of portable, accurate, and cost-efficient point-of-care diagnostic systems.
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Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.
TL;DR: The challenges that must be overcome before MSC-based tissue engineering can become a front-line technology for successful articular cartilage regeneration are highlighted.
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SEQUENTIAL EXPOSURE TO FIBROBLAST GROWTH FACTORS (FGF) 2, 9 AND 18 ENHANCES hMSC CHONDROGENIC DIFFERENTIATION
Diego Correa,Rodrigo A. Somoza,Paul Lin,Steven Greenberg,Eran Rom,Lori Duesler,Jean F. Welter,Avner Yayon,Arnold I. Caplan +8 more
TL;DR: The effects of sequential exposure to FGF2, 9 and 18 on human Mesenchymal Stem Cells (hMSC) differentiation during in vitro chondrogenesis could be used to optimize pre-implantation conditions of hMSC when used to engineer cartilage grafts.
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Intranigral Transplantation of Epigenetically Induced BDNF-Secreting Human Mesenchymal Stem Cells: Implications for Cell-Based Therapies in Parkinson's Disease
Rodrigo A. Somoza,Carlos Juri,Mauricio Baes,Ursula Wyneken,Francisco Javier Rubio,Francisco Javier Rubio +5 more
TL;DR: HMSC cultures exposed to the described induction medium might be highly useful as a vehicle for neurotrophic delivery to the brain and specifically are strong candidates for future therapeutic application in Parkinson's disease.
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Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche.
TL;DR: It is reported that local MSCs, acting as pericytes, regulate the extravasation of melanoma cancer cells (MCC) specifically to murine bone marrow (BM) and liver.