Yan Li

TL;DR: A comprehensive chromatin interaction map generated in human fibroblasts using a genome-wide 3C analysis method (Hi-C) is reported and suggests that the three-dimensional chromatin landscape, once established in a particular cell type, is relatively stable and could influence the selection of target genes by a ubiquitous transcription activator in a cell-specific manner.

TL;DR: It is found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in nonexpressing lineages, while promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression.

TL;DR: The first CRISPR Cas12a (cpf1) based electrochemical biosensor (E-CRISPR) is reported, which is more cost-effective and portable comparing with optical transduction based biosensing systems and could be a powerful enabler for wide developments of portable, accurate, and cost-efficient point-of-care diagnostic systems.

TL;DR: It is reported here that the chromatin histone H3-lysine 4 methyltransferase, SET7/9, is a novel coactivator of NF-κB, and a novel role for SET 7/9 in inflammation and diabetes is demonstrated.

TL;DR: It is reported that epigenetic priming of enhancers signifies developmental competence during endodermal lineage diversification and identifies the acquisition of a poised chromatin state at enhancers as a mechanism by which progenitor cells acquire developmental competence.