R
Rohini Kuner
Researcher at Heidelberg University
Publications - 172
Citations - 10071
Rohini Kuner is an academic researcher from Heidelberg University. The author has contributed to research in topics: Nociception & Chronic pain. The author has an hindex of 51, co-authored 148 publications receiving 8068 citations. Previous affiliations of Rohini Kuner include Molecular Medicine Partnership Unit.
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Journal ArticleDOI
Central mechanisms of pathological pain
TL;DR: This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches.
Journal ArticleDOI
Role of heteromer formation in GABAB receptor function.
Rohini Kuner,Georg Köhr,Sylvia Grünewald,Gisela Eisenhardt,Alfred Bach,Hans-Christian Kornau +5 more
TL;DR: The interaction of these receptors appears to be crucial for important physiological effects of GABA and provides a mechanism in receptor signaling pathways that involve a heterotrimeric GTP-binding protein.
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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal,Pal Pacher,Irmgard Tegeder,Fumimasa Amaya,Cristina E. Constantin,Gary J. Brenner,Tiziana Rubino,Christoph W. Michalski,Giovanni Marsicano,Krisztina Monory,Ken Mackie,Claudiu Marian,Sandor Batkai,Daniela Parolaro,Michael Fischer,Peter W. Reeh,George Kunos,Michaela Kress,Beat Lutz,Clifford J. Woolf,Rohini Kuner +20 more
TL;DR: It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
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Structural plasticity and reorganisation in chronic pain.
Rohini Kuner,Herta Flor +1 more
TL;DR: This Review discusses maladaptive structural plasticity in neural circuits of pain, spanning multiple anatomical and spatial scales in animal models and human patients, and addresses key questions on structure–function relationships.
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Neuropathic Pain: From Mechanisms to Treatment
TL;DR: Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life and the major classes of therapeutics include drugs acting on α2 δsubunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways.