C
Claudiu Marian
Researcher at Goethe University Frankfurt
Publications - 10
Citations - 1397
Claudiu Marian is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Nociception & Neuropathic pain. The author has an hindex of 10, co-authored 10 publications receiving 1333 citations.
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Journal ArticleDOI
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder,Michael Costigan,Robert S. Griffin,Andrea Abele,Inna Belfer,Helmut Schmidt,Corina Ehnert,Jemiel Nejim,Jemiel Nejim,Claudiu Marian,Joachim Scholz,Tianxia Wu,Andrew Allchorne,Luda Diatchenko,Alexander M. Binshtok,David Goldman,Jan Adolph,Swetha Sama,Steven J. Atlas,William A. Carlezon,Aram Parsegian,Jörn Lötsch,Roger B. Fillingim,William Maixner,Gerd Geisslinger,Mitchell B. Max,Clifford J. Woolf +26 more
TL;DR: It is reported that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain.
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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal,Pal Pacher,Irmgard Tegeder,Fumimasa Amaya,Cristina E. Constantin,Gary J. Brenner,Tiziana Rubino,Christoph W. Michalski,Giovanni Marsicano,Krisztina Monory,Ken Mackie,Claudiu Marian,Sandor Batkai,Daniela Parolaro,Michael Fischer,Peter W. Reeh,George Kunos,Michaela Kress,Beat Lutz,Clifford J. Woolf,Rohini Kuner +20 more
TL;DR: It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
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Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats.
Joachim Scholz,Andrea Abele,Claudiu Marian,Annett Häussler,Teri A. Herbert,Clifford J. Woolf,Irmgard Tegeder,Irmgard Tegeder +7 more
TL;DR: It is confirmed that microglial activation is crucial for the development of pain after nerve injury, and it is demonstrated that suppression of this cellular immune response is a promising approach for preventing neuropathic pain.
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R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.
Philipp Bishay,Helmut Schmidt,Claudiu Marian,Annett Häussler,Nina Wijnvoord,Simone Ziebell,Julia Metzner,Marco Koch,Thekla Myrczek,Ingo Bechmann,Rohini Kuner,Michael Costigan,Faramarz Dehghani,Gerd Geisslinger,Irmgard Tegeder +14 more
TL;DR: The results suggest that R-flurbiprofen improves the endogenous mechanisms to regain stability after axonal injury and to fend off chronic neuropathic pain by modulating the endocannabinoid system and thus constitutes an attractive, novel therapeutic agent in the treatment of chronic, intractable pain.
Journal ArticleDOI
Antinociceptive activity of the S1P-receptor agonist FTY720.
Ovidiu Coste,Sandra Pierre,Claudiu Marian,Christian Brenneis,Carlo Angioni,Helmut Schmidt,Laura Popp,Gerd Geisslinger,Klaus Scholich +8 more
TL;DR: Surprisingly, intrathecally administered FTY720 reduced the nociceptive behaviour in the formalin assay without altering spinal prostaglandin synthesis, indicating that additional antinocICEptive mechanisms beside the inhibition of prostag landin synthesis are involved.