R
Roland J. Levinsky
Researcher at University of London
Publications - 107
Citations - 7570
Roland J. Levinsky is an academic researcher from University of London. The author has contributed to research in topics: X-linked agammaglobulinemia & Gene. The author has an hindex of 34, co-authored 106 publications receiving 7391 citations. Previous affiliations of Roland J. Levinsky include University College London & UCL Institute of Child Health.
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Prolonged survival and late presentation of vertically transmitted HIV infection in childhood.
TL;DR: The clinical and immunological findings in a symptomless human immunodeficiency virus (HIV) carrier and her 2 sons 4 and 8 years after presumed vertical transmission are discussed.
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The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.
Giles O. Cory,Ruth C. Lovering,S. Hinshelwood,L. Maccarthy-Morrogh,Roland J. Levinsky,Christine Kinnon +5 more
TL;DR: A 120-kD protein present in human B cells is identified as being bound by the SH3 domain of Btk and which, after B cell receptor stimulation, is one of the major substrates of tyrosine phosphorylation.
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Adeno-Associated Virus Gene Transfer to Mouse Retina
Robin R. Ali,MB Reichel,M De Alwis,Naheed Kanuga,Christine Kinnon,Roland J. Levinsky,David M. Hunt,Shomi S. Bhattacharya,Adrian J. Thrasher +8 more
TL;DR: It is shown that highly purified recombinant AAV vectors encoding the reporter gene LacZ transduce photoreceptors in an immunocompetent mouse strain following subretinal injection and efficientlytransduce ganglion cells after intravitreal injection.
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Preparative procedures of cooling and re-warming increase leukocyte integrin expression and function on neotrophils
TL;DR: The results indicate that the cooling of neutrophils during isolation is an inappropriate method of neutrophic preparation, probably causing translocation of intracellular stores of the leukocyte integrins to the cell surface in a manner analogous to the stimulant FMLP.
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Expression of Bruton's tyrosine kinase protein within the B cell lineage
Helen C. Genevier,Steve Hinshelwood,Hubert B. Gaspar,Kevin Rigley,Derek Brown,Sem Saeland,Françoise Rousset,Roland J. Levinsky,Robin E. Callard,Christine Kinnon,Ruth C. Lovering +10 more
TL;DR: An antiserum is developed which recognizes the human Btk protein and it is shown that normal human tonsillar B cells, peripheral blood monocytes and myeloid cells express the protein, whereas tonsil‐derived T cells do not.